INHIBITION OF HUMAN PULMONARY PHOSPHODIESTERASE ACTIVITY BY THERAPEUTIC LEVELS OF THEOPHYLLINE
INHIBITION OF HUMAN PULMONARY PHOSPHODIESTERASE ACTIVITY BY THERAPEUTIC LEVELS OF THEOPHYLLINE
复制标题
茶碱治疗水平对人肺磷酸二酯酶活性的抑制
DOI：
10.1111/j.1440-1681.1978.tb00707.x
复制
发表时间：
1978
影响因子：
2.9
通讯作者：
Andor Szentivanyi
中科院分区：
文献类型：
--
作者：
J. B. Poison;J. Krzanowski;Allan L. Goldman;Andor Szentivanyi
1.为了检验环核苷酸磷酸二酯酶抑制是茶碱在可逆性气道疾病中的支气管扩张作用的主要机制这一假设，检查了药物的治疗血浆水平对人肺磷酸二酯酶活性的影响。
1. To test the hypothesis that inhibition of cyclic nucleotide phosphodiesterase is the major mechanism of the bronchodilator action of theophylline in reversible airways disease, the effects of therapeutic plasma levels of the drug on human pulmonary phosphodiesterase activity were examined.