Imaging Patterns of Brain Development and their Relationship to Cognition
Imaging Patterns of Brain Development and their Relationship to Cognition
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DOI：
10.1093/cercor/bht425
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发表时间：
2015-06-01
期刊：
影响因子：
3.7
通讯作者：
Gur, Ruben C.
中科院分区：
文献类型：
--
作者：
Erus, Guray;Battapady, Harsha;Gur, Ruben C.
我们提出了一个大脑发育指数（BDI），简明扼要地总结了复杂的成像模式的结构脑成熟沿着一个单一的维度使用机器学习方法。在费城神经发育队列中，年龄在8-22岁的621名受试者的样本中发现大脑遵循非常一致的发育轨迹，这反映在年龄和BDI之间的交叉验证相关系数r = 0.89。至关重要的是，偏离这一轨迹与认知表现有关。具体而言，与BDI低于实际年龄的受试者相比，BDI高于实际年龄的受试者显示出显著的上级认知处理速度。这些结果表明，BDI总结的多参数成像模式可以准确地描绘大脑发育的轨迹，并识别认知早熟或延迟的个体。
We present a brain development index (BDI) that concisely summarizes complex imaging patterns of structural brain maturation along a single dimension using a machine learning methodology. The brain was found to follow a remarkably consistent developmental trajectory in a sample of 621 subjects of ages 8-22 participating in the Philadelphia Neurodevelopmental Cohort, reflected by a cross-validated correlation coefficient between chronologic age and the BDI of r = 0.89. Critically, deviations from this trajectory related to cognitive performance. Specifically, subjects whose BDI was higher than their chronological age displayed significantly superior cognitive processing speed compared with subjects whose BDI was lower than their actual age. These results indicate that the multiparametric imaging patterns summarized by the BDI can accurately delineate trajectories of brain development and identify individuals with cognitive precocity or delay.