Validity of protein, retinol, folic acid and n-3 fatty acid intakes estimated from the food-frequency questionnaire used in the Danish National Birth Cohort
Validity of protein, retinol, folic acid and n-3 fatty acid intakes estimated from the food-frequency questionnaire used in the Danish National Birth Cohort
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DOI：
10.1079/phn2005883
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发表时间：
2006-09-01
影响因子：
3.2
通讯作者：
Olsen, Sjurdur F.
中科院分区：
文献类型：
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作者：
Mikkelsen, Tina B.;Osler, Merete;Olsen, Sjurdur F.
目的验证妊娠第25周食物频率问卷（FFQ-25）估计的蛋白质、叶酸、视黄醇和n-3脂肪酸的摄入量。根据妊娠32-38周的7天称重食物日记（FD）和营养物质的生物标志物进行设计验证。待验证的FFQ-25在丹麦国家出生队列中使用，该队列包括101042名丹麦孕妇，其中88人参加了本验证研究。结果蛋白质、视黄醇和叶酸的估计摄入量在两种饮食方法之间没有显著差异，但n-3脂肪酸的摄入量比FFQ-25估计的多三分之一。从两种饮食方法估计的摄入量都是显著相关的，从视黄醇摄入量的0.20到叶酸摄入量的0.57。正确划分高、低五分位数的敏感性在0.22 ~ 0.77之间，特异性在0.62 ~ 0.89之间。尿蛋白含量与FFQ估算的蛋白质没有显著相关性（r=0.17, P < 0.05），但与FD估算的摄入量有显著相关性（r=0.56, P < 0.0001）。红细胞叶酸与预估的FFQ总摄入量（r=0.55, P < 0.0001）和FD总摄入量（r=0.52, P < 0.0001）显著相关。与血浆视黄醇无相关性。红细胞二十碳五烯酸（C20:5n-3）与FFQ-25 （r=0.37, P < 0.001）和FD （r=0.62, P < 0.0001）估算的n-3脂肪酸摄入量显著相关。结论FFQ-25对蛋白质、视黄醇和叶酸的摄入量给出了合理有效的估计，但对n-3脂肪酸的摄入量估计过高。
Objective To validate intakes of protein, folic acid, retinol and n-3 fatty acids estimated from a food-frequency questionnaire in week 25 of pregnancy (FFQ-25).Design Validation was done against a 7-day weighed food diary (FD) and biomarkers of the nutrients in gestation week 32-38.Subjects and setting The FFQ-25 to be validated was used in the Danish National Birth Cohort comprising 101 042 pregnant Danish women, of whom 88 participated in the present validation study.Results Estimated intakes of protein, retinol and folic acid did not differ significantly between the two dietary methods, but intake of n-3 fatty acids was one third larger when estimated from the FFQ-25. The intakes estimated from the two dietary methods were all significantly correlated, ranging from 0.20 for retinol intake to 0.57 for folic acid intake. Sensitivities of being correctly classified into low and high quintiles were between 0.22 and 0.77, and specificities were between 0.62 and 0.89. Urinary protein content did not correlate significantly with protein estimated from the FFQ (r=0.17, P > 0.05), but did with intake estimated from the FD (r=0.56, P < 0.0001). Erythrocyte folate correlated significantly with the estimated total intake from the FFQ (r=0.55, P < 0.0001) and the FD (r=0.52, P < 0.0001). No correlations with plasma retinol were found. Erythrocyte eicosapentaenoic acid (C20:5n-3) correlated significantly with n-3 fatty acids intake estimated from both the FFQ-25 (r=0.37, P < 0.001) and the FD (r=0.62, P < 0.0001).Conclusion The FFQ-25 gives reasonable valid estimates of protein, retinol and folic acid intakes, but seems to overestimate intake of n-3 fatty acids.