Common Type 2 Diabetes Risk Gene Variants Associate with Gestational Diabetes
Common Type 2 Diabetes Risk Gene Variants Associate with Gestational Diabetes
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DOI：
10.1210/jc.2008-1336
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发表时间：
2009-01-01
影响因子：
5.8
通讯作者：
Hansen, Torben
中科院分区：
文献类型：
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作者：
Lauenborg, Jeannet;Grarup, Niels;Hansen, Torben
目的：我们旨在检查妊娠期糖尿病 (GDM) 与 11 个最近确定的 2 型糖尿病易感位点之间的关联。 研究设计和方法：TCF7L2、CDKAL1、SLC30A8、HHEX/IDE、CDKN2A/2B、IGF2BP2、FTO、TCF2、PPARG、 在具有 GDM 病史的女性队列 (n = 283) 和基于人群的 Inter99 队列中的耐糖女性 (n = 2446) 中对 KCNJ11 和 WFS1 基因座进行了基因分型。 结果：11 个检查的 2 型糖尿病风险变异中的所有风险等位基因显示，与对照组相比，GDM 组的比值比 (OR) 大于 1，范围为 1.13 [95% 置信区间 (CI) 0.88-1.46] 至 1.44 (95% CI 1.19-1.74)，但 WFS1 rs10010131 变体 OR 0.87 (95% CI 0.73-1.05) 除外。所有 11 个变异的综合分析显示，多个风险等位基因对 GDM 风险具有高度显着的累加效应 [OR 1.18 (95% CI 1.10-1.27)] 每个风险等位基因，P = 3.2 x 10(-6)）。应用受试者工作特征显示，单独进行基因检测时，受试者工作特征曲线下面积为 0.62，结合年龄、体重指数和 11 个基因变异基因型的信息时，受试者工作特征曲线下面积为 0.73。 结论：既往 GDM 组中几个先前已证实的 2 型糖尿病风险等位基因的患病率与 2 型糖尿病关联研究的结果相同。这支持了 GDM 和 2 型糖尿病是同一实体的两个假设。 (临床内分泌代谢杂志 94: 145-150, 2009)
Objective: We aimed to examine the association between gestational diabetes mellitus (GDM) and 11 recently identified type 2 diabetes susceptibility loci.Research Design and Methods: Type 2 diabetes risk variants in TCF7L2, CDKAL1, SLC30A8, HHEX/IDE, CDKN2A/2B, IGF2BP2, FTO, TCF2, PPARG, KCNJ11, and WFS1 loci were genotyped in a cohort of women with a history of GDM (n = 283) and glucose-tolerant women of the population-based Inter99 cohort (n = 2446).Results: All the risk alleles in the 11 examined type 2 diabetes risk variants showed an odds ratio (OR) greater than 1 for the GDM group compared with the control group ranging from 1.13 [95% confidence interval (CI) 0.88-1.46] to 1.44 (95% CI 1.19-1.74) except for the WFS1 rs10010131 variant with OR 0.87 (95% CI 0.73-1.05). Combined analysis of all 11 variants showed a highly significant additive effect of multiple risk alleles on risk of GDM [OR 1.18 (95% CI 1.10-1.27)] per risk allele, P = 3.2 x 10(-6)). Applying receiver- operating characteristic showed an area under the receiver- operating characteristic curve of 0.62 for the genetic test alone and 0.73 when combining information on age, body mass index, and genotypes of the 11 gene variants.Conclusions: The prevalence in a prior GDM group of several previously proven type 2 diabetes risk alleles equals the findings from association studies on type 2 diabetes. This supports the hypothesis that GDM and type 2 diabetes are two of the same entity. (J Clin Endocrinol Metab 94: 145-150, 2009)