Postprandial and orthostatic hypotension in Parkinson's disease
Postprandial and orthostatic hypotension in Parkinson's disease
复制标题
帕金森病的餐后和体位性低血压
作者：
Giuseppe Micieli;E. Martignoni;Anna Cavallini;Giorgio Sandrini;G. Nappi
在这项研究中，在13名未经治疗的帕金森病患者中研究了血压（BP）、心率和尿儿茶酚胺（CA）排泄的24小时模式以及BP和血浆CA对倾斜试验的反应。疾病（PD）和11名年龄匹配的健康对照。13例PD受试者中有7例显示仰卧位收缩压下降幅度大于对照组（即超过餐前值的20%）。PD组餐后低血压程度与24小时多巴胺排泄平均值之间存在显著相关性。8例PD受试者在倾斜试验（在早晨进行）和餐后阶段也显示直立性低血压。PD患者的基础去甲肾上腺素血浆水平及其站立时的百分比增加均在对照组的范围内。这些数据表明存在一种PD患者亚型，其特征为心血管反应性的广泛损害，并接近自主神经功能衰竭综合征，如进行性自主神经功能衰竭或多系统萎缩，或两者兼而有之。
In this study, the 24-hour pattern of blood pressure (BP), heart rate, and urinary catecholamine (CA) excretion and the response of BP and plasma CA to the tilt test have been investigated in 13 untreated patients affected by Parkinson's disease (PD) and in 11 age-matched healthy controls. Seven of the 13 PD subjects showed a fall of supine systolic BP greater than that in controls (ie, exceeding 20% of the preprandial value). A significant relationship was found in the PD group between the degree of postprandial hypotension and the 24-hour mean value of dopamine excretion. Eight PD subjects also showed orthostatic hypotension during the tilt test (performed in the morning hours) and in the postprandial phase. Basal norepinephrine plasma levels of PD patients, as well as their percentage increases on standing, were within the range of the controls. These data suggest the existence of a subtype of PD patient, characterized by a widespread impairment of cardiovascular responsiveness and bordering on syndromes of autonomic failure such as progressive autonomic failure or multiple system atrophy, or both.
影响因子：
9.3
作者：
Anderson,GM;Young,JG;Jatlow,PI;Cohen,DJ
通讯作者：
Cohen,DJ