Cell-mediated immunity to liver antigen in toxic liver injury. II. Role in pathogenesis of liver damage.
Cell-mediated immunity to liver antigen in toxic liver injury. II. Role in pathogenesis of liver damage.
复制标题
中毒性肝损伤中细胞介导的对肝抗原的免疫。
DOI：
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发表时间：
1980
影响因子：
4.6
通讯作者：
L. Powell
中科院分区：
文献类型：
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作者：
C. Smith;W. Cooksley;L. Powell
用四氯化碳（CCl_4）诱发CBA小鼠亚致死性肝坏死，观察肝抗原致敏淋巴细胞的致病作用。将CCl4处理小鼠的致敏淋巴细胞给予同基因受体。受体对肝抗原产生了敏感性，但没有肝损伤的证据。在供体和受体中介导免疫应答的细胞是T细胞。这一点在涉及T细胞缺陷小鼠的研究中得到了进一步证明。这些小鼠在接受CCl4治疗时没有产生致敏淋巴细胞，但T细胞耗尽和完整动物的肝损伤程度相似。这些结果表明，T细胞致敏肝抗原发生的结果，毒性肝损伤，并没有发挥作用的肝坏死的发病机制。
The possible pathogenetic role of lymphocytes sensitized to liver antigens was investigated in CBA mice in which sublethal hepatic necrosis had been induced by carbon tetrachloride (CCl4). Sensitized lymphocytes from CCl4-treated mice were administered to syngeneic recipients. The recipients developed sensitivity to liver antigens but showed no evidence of liver damage. The cell mediating the immune response both in the donor and the recipient was a T cell. This was demonstrated further by studies involving mice rendered T cell deficient. These mice did not develop sensitized lymphocytes when they were treated with CCl4 but the extent of liver damage was similar in both T cell-depleted and intact animals. These findings suggest that T cell sensitization to liver antigens occurs as a result of toxic liver damage and does not play a role in the pathogenesis of the hepatic necrosis.