Meridianin D analogues possess antibiofilm activity against Mycobacterium smegmatis
Meridianin D analogues possess antibiofilm activity against Mycobacterium smegmatis
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DOI：
10.1039/c9md00466a
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发表时间：
2020-01-01
影响因子：
4.1
通讯作者：
Melander, Christian
中科院分区：
文献类型：
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作者：
Brackett, Sara M.;Cox, Karlie E.;Melander, Christian
细菌生物膜的形成显著降低了抗生素治疗的功效。在此，我们研究了天然产物黄曲霉素D和一个抗耻垢分枝杆菌类似物库的生物膜特性。结果，我们发现了几种既能抑制又能分散M.粪污生物膜。
The formation of bacterial biofilms significantly decreases the efficacy of antibiotic treatments. Herein, we've investigated the antibiofilm properties of the natural product meridianin D and a library of analogues against Mycobacterium smegmatis. As a result, we discovered several analogues that both inhibit and disperse M. smegmatis biofilms.