T cell receptor (TCR) repertoire in alloimmune responses.
T cell receptor (TCR) repertoire in alloimmune responses.
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DOI：
10.3109/08830189609061747
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发表时间：
1996-01-01
影响因子：
5
通讯作者：
Bishop, D K
中科院分区：
文献类型：
--
作者：
Finn, O J;Debruyne, L A;Bishop, D K
大量的同种抗原决定簇可以通过直接和间接的同种抗原提呈途径产生。因此，预期表达多种受体的异质性T细胞群体会对这种多样的同种异体抗原决定簇作出反应。然而，表达高度限制性T细胞受体（TCR）可变基因的T细胞已被报道在各种同种免疫反应。类似的现象已经在各种各样的其他免疫应答中观察到，从由超抗原诱导的免疫应答到由单个MHC分子呈递的单个肽诱导的非常特异性的应答。鉴于这种情况，可以凭借选定的TCR表达来治疗靶向主导同种异体移植排斥反应（或就此而言的自身免疫反应或肿瘤特异性反应）的有限数量的T细胞克隆。
A large number of alloantigenic determinants could be generated by both the direct and indirect alloantigen presentation pathways. Hence, a heterogeneous population of T cells expressing a wide variety of receptors would be expected to respond to this diverse array of alloantigenic determinants. However, T cells expressing highly restricted T cell receptor (TCR) variable genes have been reported in a variety of alloimmune responses. A similar phenomenon has been observed in a wide variety of other immune responses, from those induced by superantigens, to very specific responses induced by a single peptide presented by a single MHC molecule. Given this scenario, the limited number of T cell clones which dominate an allograft rejection response, or for that matter an autoimmune response or a tumor specific response, could be therapeutically targeted by virtue of the selected TCR expression.