Heart Rate-Dependence of QTc Intervals Assessed by Different Correction Methods in Patients with Normal or Prolonged Repolarization
Heart Rate-Dependence of QTc Intervals Assessed by Different Correction Methods in Patients with Normal or Prolonged Repolarization
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DOI：
10.1111/j.1540-8159.2009.02657.x
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发表时间：
2010-05-01
影响因子：
1.8
通讯作者：
Alexopoulos, Dimitrios
中科院分区：
文献类型：
--
作者：
Chiladakis, John;Kalogeropoulos, Andreas;Alexopoulos, Dimitrios
研究方法：研究患者（n = 123，年龄68 +/- 11岁）为基线QT间期正常或延长的双腔器械接受者，保留了固有心室激动伴窄QRS波群。患者分为正常QT（n = 69）或延长QT（n = 54）组。在基线（每分钟52 +/- 3次）和心房起搏阶段后以每分钟60、80和100次记录连续QT间期。结果：心率对QTc的影响有显著性意义（P < 0.05），心率对QTc的影响不受公式的影响（P> 0.05）。Bazett公式显示两个患者组中心率阶段的QTc变异性最高（最高F值）（在总队列中，F = 175.9）。在下面的排名顺序中，公式Hodges，Karjalainen-Nomogram，Sagie-Fraidia和Fridericia在两个患者组中在较慢和较快的心率下显示出相似的QTc心率依赖性（F = 21.8，25.6，28.8，36.9，在总队列中，分别）。结论：在所研究的QTc公式中，Bazett出现了最多的心率依赖性。我们的研究结果表明，使用Hodges和Karjalainen列线图其次，以确保最小的心率依赖性的QTc间期的患者无论是正常的或延长复极。(PACE 2010; 553-560）。
Methods: Study patients (n = 123, age 68 +/- 11 years) were dual-chamber device recipients with baseline normal or prolonged QT interval who had preserved intrinsic ventricular activation with narrow QRS complexes. Patients were classified to either Normal-QT (n = 69) or Prolonged-QT (n = 54) groups. Serial QT intervals were recorded at baseline (52 +/- 3 beats per minute) and following atrial pacing stages at 60, 80, and 100 beats per minute. The QTc formulae of Bazett, Fridericia, Sagie-Framingham, Hodges, and Karjalainen-Nomogram were applied to assess the effect of heart rate on the derived QTc values by using linear mixed-effects models.Results: Heart rate had a significant effect on QTc regardless of the formula used (P < 0.05 for all formulae). The Bazett's formula demonstrated the highest QTc variability across heart rate stages (highest F values) in both patient groups (in the total cohort, F = 175.9). In the following rank order, the formulae Hodges, Karjalainen-Nomogram, Sagie-Framingham, and Fridericia showed similar QTc heart rate dependence at both slower and faster heart rates in both patient groups (F = 21.8, 25.6, 28.8, 36.9, in the total cohort, respectively).Conclusions: Of the studied QTc formulae, the Bazett appeared the most heart rate dependent. Our results suggest the use of Hodges and the Karjalainen-Nomogram secondly to ensure least heart rate dependence of QTc intervals in patients with either normal or prolonged repolarization. (PACE 2010; 553-560).