Secretion and renal effects of ANF prohormone peptides.
Secretion and renal effects of ANF prohormone peptides.
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ANF 激素原肽的分泌和肾脏影响。
DOI：
10.1111/j.1440-1681.1995.tb01966.x
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发表时间：
1995
影响因子：
2.9
通讯作者：
Nazian,SJ
中科院分区：
文献类型：
--
作者：
Dietz,JR;Vesely,DL;GowerJr,WR;Nazian,SJ
1.心房利钠因子（ANF）和前ANF肽似乎是同时分泌的心房，以响应心房牵张。2.从大鼠心房分泌的主要肽形式似乎是作为主要C-末端肽的ANF（pro ANF 99-126）和作为主要N-末端肽的pro ANF 1-30，而不是1-67或1-98。3.血浆ANF和前ANF 1-30的浓度通过血容量扩张的急性刺激而增加，并且血浆ANF和N-末端ANF前激素肽的水平通过高盐饮食而慢性升高。4. Pro ANF 31-67产生尿钠排泄，其不依赖于肾cGMP排泄的增加、血浆肾素活性（PRA）的降低或血浆ANF浓度的升高。
1. Atrial natriuretic factor (ANF) and pro ANF peptide appears to be secreted simultaneously from the atria in response to atrial stretch. 2. The major peptide forms secreted from rat atria appear to be ANF (pro ANF 99-126) as the primary C-terminal peptide and pro ANF 1-30 as the primary N-terminal peptide, as opposed to 1-67 or 1-98. 3. The plasma concentrations of ANF and pro ANF 1-30 are increased by acute stimulation with blood volume expansion and the plasma levels of ANF and N-terminal ANF prohormone peptides are chronically elevated by high salt diet. 4. Pro ANF 31-67 produces a natriuresis which is not dependent on an increase in renal cGMP excretion, decreases in plasma renin activity (PRA) or elevations in plasma ANF concentration.