Thermo-responsive recoverable polymeric inhibitors for the resolution of racemic amino acids
Thermo-responsive recoverable polymeric inhibitors for the resolution of racemic amino acids
复制标题
用于拆分外消旋氨基酸的热响应性可恢复聚合物抑制剂
DOI：
10.1039/c8cc00333e
复制
发表时间：
2018
影响因子：
4.9
通讯作者：
Wan Xinhua
中科院分区：
文献类型：
--
作者：
Ye Xichong;Zhang Jie;Cui Jiaxi;Wan Xinhua
新型聚合物抑制剂具有较低的临界溶液温度在水中制备和用于介导的外消旋天冬酰胺一水合物的结晶，导致手性分离与88.6 ee%。它们可以通过简单地升高温度以约95%的高产率回收，并且在不损害立体选择性和稳定性的情况下重复使用。
Novel polymeric inhibitors with lower critical solution temperatures in water were prepared and used to mediate the crystallization of racemic asparagine monohydrate, leading to chiral separation with 88.6 ee%. They could be recollected by simply elevating the temperature with a high yield of around 95% and reused without compromising the stereoselectivity and stability.