Androgens, body fat Distribution and Adipogenesis
Androgens, body fat Distribution and Adipogenesis
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DOI：
10.1007/s13679-014-0119-6
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发表时间：
2014-12-01
影响因子：
8.8
通讯作者：
Tchernof, Andre
中科院分区：
文献类型：
--
作者：
Zerradi, Mouna;Dereumetz, Julie;Tchernof, Andre
雄激素是重要的脂肪细胞功能的调节剂，如脂肪形成、脂质储存和脂解。通过对每个脂肪隔室细胞的储库特异性影响，雄激素可以调节人体脂肪分布模式。在包括男性和女性的人脂肪细胞原代培养物在内的几种模型中，已显示替吉奥和双氢睾酮可抑制前脂肪细胞分化为贮脂脂肪细胞。还观察到雄激素对脂质代谢的一些标志物如LPL活性、脂肪酸摄取和脂解的影响。在一些但不是所有的模型中观察到了可能的特定贮库和特定性别效应。雄激素前体转化为活性雄激素或它们被脂肪组织中表达和起作用的酶灭活可能有助于调节活性激素的局部可用性。这些现象，沿着与糖皮质激素的假定的储库特异性相互作用，可能有助于人体脂肪分布模式。
Androgens are regulators of important adipocyte functions such as adipogenesis, lipid storage, and lipolysis. Through depot-specific impact on the cells of each fat compartment, androgens could modulate body fat distribution patterns in humans. Testosterone and dihydrotestosterone have been shown to inhibit the differentiation of preadipocytes to lipid-storing adipocytes in several models including primary cultures of human adipocytes from both men and women. Androgen effects have also been observed on some markers of lipid metabolism such as LPL activity, fatty acid uptake, and lipolysis. Possible depot-specific and sex-specific effects have been observed in some but not all models. Transformation of androgen precursors to active androgens or their inactivation by enzymes that are expressed and functional in adipose tissue may contribute to modulate the local availability of active hormones. These phenomena, along with putative depot-specific interactions with glucocorticoids may contribute to human body fat distribution patterns.