Roles of MAPKKK ASK1 in stress-induced cell death.
Roles of MAPKKK ASK1 in stress-induced cell death.
复制标题
DOI：
10.1247/csf.28.23
复制
发表时间：
2003-02
影响因子：
1.5
通讯作者：
K. Takeda;A. Matsuzawa;H. Nishitoh;H. Ichijo
中科院分区：
文献类型：
--
作者：
K. Takeda;A. Matsuzawa;H. Nishitoh;H. Ichijo
凋亡信号调节激酶1 （Apoptosis signal- regulatory kinase 1, ASK1）是一种普遍表达的丝裂原活化蛋白激酶（MAP）激酶，可激活c-Jun n-末端激酶（JNK）和p38 MAP激酶信号级联反应。最近对ASK1缺陷小鼠的分析发现，ASK1是氧化应激、TNF和内质网（ER）应激诱导的细胞凋亡所必需的。此外，一些证据表明，ASK1在决定细胞命运方面具有多种功能，而不是其促凋亡活性。因此，ASK1似乎不仅在应激诱导的细胞死亡中起关键作用，而且在细胞适应或对抗各种应激的广泛生物活动中也起关键作用。
Apoptosis signal-regulating kinase 1 (ASK1) is a ubiquitously expressed mitogen-activated protein (MAP) kinase kinase kinase that activates the c-Jun N-terminal kinase (JNK) and p38 MAP kinase signaling cascades. Recent findings from analyses of ASK1-deficient mice have revealed that ASK1 is required for apoptosis induced by oxidative stress, TNF and endoplasmic reticulum (ER) stress. In addition, several lines of evidence have suggested that ASK1 has diverse functions in the decision of cell fate beyond its pro-apoptotic activity. Thus, ASK1 appears to be a pivotal component not only in stress-induced cell death but also in a broad range of biological activities in order for cells to adapt to or oppose various stresses.