Cdx-2 homeodomain protein expression in human and rat colorectal adenoma and carcinoma.
Cdx-2 homeodomain protein expression in human and rat colorectal adenoma and carcinoma.
复制标题
Cdx-2 同源域蛋白在人和大鼠结直肠腺瘤和癌中的表达。
DOI：
--
复制
发表时间：
1995
影响因子：
6
通讯作者：
Robert J. James
中科院分区：
文献类型：
--
作者：
Hooi C. Ee;T. Erler;S. Prithi;Bhathal;Graeme P. Young;Robert J. James
癌症在生长模式、细胞形态和癌胚抗原与胚胎组织的表达上有许多相似之处。为了更好地了解恶性转化的机制及其与发育过程的关系，我们研究了肠上皮特异性同源结构域蛋白Cdx-2在结直肠腺瘤和癌中的表达。通过免疫组化多克隆Cdx-2抗体，我们发现Cdx-2的表达在人类结直肠癌发生的晚期，即高级别非典型增生和浸润性癌中显著降低。在1,2-二甲基肼诱导的大鼠结直肠肿瘤中也出现了同样的发现，证实了大鼠模型与人类疾病之间的相似之处。由于同源结构域蛋白在指导机体部位的区域化、器官发生和细胞表型规范中起着重要作用，Cdx-2在结直肠癌发生晚期表达的降低可能反映了肿瘤组织与正常肠上皮表型的同时偏离。
Cancers share many similarities in growth patterns, cellular morphology, and oncofetal antigen expression with embryonic tissue. To better understand the mechanisms underlying malignant transformation and its relationship to developmental processes, we studied the expression of Cdx-2, an intestinal epithelium-specific homeodomain protein, in colorectal adenoma and carcinoma. By immunohistochemistry with a polyclonal Cdx-2 antibody we have shown that Cdx-2 expression is markedly reduced in the later stages of human colorectal carcinogenesis, namely, high grade dysplasia and invasive carcinoma. The same findings occur in 1,2-dimethylhydrazine-induced rat colorectal tumors, confirming the parallels between the rat model and the human disease. As homeodomain proteins play major roles in directing the regionalization of body parts and in organogenesis and cellular phenotypic specification, a reduction of Cdx-2 expression in the late stages of colorectal carcinogenesis may reflect a concomitant deviation of the neoplastic tissue from the normal intestinal epithelial phenotype.
肝脏作为干细胞和谱系系统。
DOI：
10.1152/ajpgi.1992.263.2.g139
发表时间：
1992
期刊：
The American journal of physiology
影响因子：
--
作者：
Sigal,SH;Brill,S;Fiorino,AS;Reid,LM
通讯作者：
Reid,LM
脱氧核糖核酸结合同源框蛋白在人类癌症中增强。
DOI：
--
发表时间：
1990
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Wewer,UM;Mercurio,AM;Chung,SY;Albrechtsen,R
通讯作者：
Albrechtsen,R