The interstitial stem cells in Hydractinia and their role in regeneration
The interstitial stem cells in Hydractinia and their role in regeneration
复制标题
DOI：
10.1016/j.gde.2016.06.006
复制
发表时间：
2016-10-01
影响因子：
4
通讯作者：
Frank, Uri
中科院分区：
文献类型：
--
作者：
Gahan, James M.;Bradshaw, Brian;Frank, Uri
一个多世纪以来，水螅物种一直是发育生物学和比较免疫学中的动物模型，但由于越来越多的研究人员利用现代遗传和基因组工具建立了现代遗传和基因组工具，水螅物种正在复兴。 Hydractinia 具有可预测且可访问的生命周期，其干细胞系统（称为间质细胞或 i 细胞）自 1800 年代末以来一直是动物干细胞的范例。在成年水螅中，i-cell 不断提供祖细胞来维持克隆生长、组织稳态、有性生殖和再生。我们回顾了以这种动物为中心的干细胞和再生研究的最新进展。在这些学科快速发展的时代，Hydractinia 加入了一个已建立的刺胞动物遗传模型团队。虽然每种动物都特别适合特定的实验环境，但它们共同可以提供对动物干细胞系统多样性、它们如何驱动再生以及它们如何进化的综合见解。
Hydractinia species have been animal models in developmental biology and comparative immunology for over a century, but are having a renaissance due to the establishment of modern genetic and genomic tools by the growing community of researchers utilizing them. Hydractinia has a predictable and accessible life cycle and its stem cell system, known as interstitial- or i-cells has been a paradigm for animal stem cells since the late 1800s. In adult Hydractinia, i-cells continuously provide progenitors to sustain clonal growth, tissue homeostasis, sexual reproduction and regeneration. We review recent developments in stem cell and regeneration research centered on this animal. Hydractinia joins an established team of cnidarian genetic models in times of rapid progress in these disciplines. While each animal is particularly suited to specific experimental settings, jointly they can provide an integrative insight into the diversity of animal stem cell systems, how they drive regeneration, and how they evolved.