Association of heat shock protein70-2 (HSP70-2) gene polymorphism with obesity
Association of heat shock protein70-2 (HSP70-2) gene polymorphism with obesity
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DOI：
10.3109/03014460.2015.1119309
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发表时间：
2016-11-01
影响因子：
1.7
通讯作者：
Ghayour-Mobarhan, Majid
中科院分区：
文献类型：
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作者：
Mardan-Nik, Maryam;Pasdar, Alireza;Ghayour-Mobarhan, Majid
背景：肥胖是慢性疾病的主要危险因素，包括心血管疾病（CVD）。越来越多的证据表明热休克蛋白 (HSP) 与 2 型糖尿病和 CVD 之间存在关联；然而，关于HSP70-2基因多态性与肥胖之间关系的数据很少。目的：本研究在伊朗人群中调查了317名受试者的1267HSP70-2基因多态性与肥胖之间的关联。对象和方法：对所有样本进行人体测量参数和生化测量，同时使用PCR-RFLP确定基因型。进行单变量/多变量分析以探讨遗传多态性与肥胖之间的关系。结果：数据显示，与非肥胖组相比，肥胖受试者中1267HSP70-2 多态性之间存在显着相关性。此外，据观察，这种多态性与 CAD+ 组的肥胖相关，与非肥胖对照组相比，该组的 BMI 较高。结论：1267HSP70-2 多态性与伊朗人群的肥胖相关，支持肥胖与心血管疾病之间可能存在潜在的遗传联系。
Background: Obesity is a major risk factor of chronic-diseases, including cardiovascular-diseases (CVD). Increasing evidence is showing the association of heat-shock protein (HSP) with type-2 diabetes and CVD; however, there is little data on the relationship between the genetic-polymorphisms of HSP70-2 with obesity.Aim: The present study has investigated the association between 1267HSP70-2 genetic polymorphism and obesity in an Iranian population with 317 subjects.Subjects and methods: Anthropometric parameters and biochemical measurements were measured in all the samples, while genotypes were determined using PCR-RFLP. Univariate/multivariate analyses were conducted to explore the relationship between the genetic-polymorphisms and obesity.Results: The data showed a significant association between 1267HSP70-2 polymorphism in obese subjects, compared to the non-obese group. Moreover, it was observed that this polymorphism was associated with obesity in the CAD+group, which had a high BMI compared to non-obese controls.Conclusion: The 1267HSP70-2 polymorphism is associated with obesity in an Iranian population, supporting a possible potential genetic link between obesity and cardiovascular diseases.