Selective hippocampal cholinergic deafferentation impairs self-movement cue use during a food hoarding task
Selective hippocampal cholinergic deafferentation impairs self-movement cue use during a food hoarding task
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DOI：
10.1016/j.bbr.2007.05.026
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发表时间：
2007-10-01
影响因子：
2.7
通讯作者：
Wallace, Douglas G.
中科院分区：
文献类型：
--
作者：
Martin, Megan A.;Wallace, Douglas G.
使用选择性病变技术的调查表明，隔海马胆碱能系统可能不是空间定位的关键。这些研究采用的空间任务，为动物提供访问环境和自我运动的线索，因此，完整的性能可能反映了备用的空间方向或补偿机制与一类空间线索。本研究通过检查操纵线索可用性的觅食任务中的表现，探讨了隔海马胆碱能系统对空间行为的贡献。13只雌性Long-Evans大鼠用192 IgG皂草素选择性损伤内侧隔/垂直带，11只接受假手术。训练大鼠在环境和自我运动线索（线索条件）的环境中搜寻榛子。操纵包括改变与避难所相关的环境线索的可用性（无线索探针），删除所有视觉环境线索（黑暗探针），并将环境和自我运动线索置于冲突中（反转探针）。内侧隔病变破坏归巢段地形只有在条件下，自我运动线索是至关重要的组织食物囤积行为（黑暗和逆转）。这些结果是一致的内侧隔病变产生的选择性损伤的自我运动线索处理，并表明这些大鼠能够补偿赤字的自我运动线索处理时提供的环境线索。(C)2007 Elsevier B. V.保留所有权利。
Investigations using selective lesion techniques suggest that the septohippocampal cholinergic system may not be critical for spatial orientation. These studies employ spatial tasks that provide the animal with access to both environmental and self-movement cues; therefore, intact performance may reflect spared spatial orientation or compensatory mechanisms associated with one class of spatial cues. The present study investigated the contribution of the septohippocampal cholinergic system to spatial behavior by examining performance in foraging tasks in which cue availability was manipulated. Thirteen female Long-Evans rats received selective lesions of the medial septum/vertical band with 192 IgG saporin, and 11 received sham surgeries. Rats were trained to forage for hazelnuts in an environment with access to both environmental and self-movement cues (cued condition). Manipulations include altering availability of environmental cues associated with the refuge (uncued probe), removing all visual environmental cues (dark probe), and placing environmental and self-movement cues into conflict (reversal probe). Medial septum lesions disrupted homeward segment topography only under conditions in which self-movement Cues were critical for organizing food hoarding behavior (dark and reversal). These results are consistent with medial septum lesions producing a selective impairment in self-movement cue processing and suggest that these rats were able to compensate for deficits in self-movement cue processing when provided access to environmental cues. (C) 2007 Elsevier B.V. All rights reserved.