Renal protective effects of chronic exercise and antihypertensive therapy in hypertensive rats with chronic renal failure
Renal protective effects of chronic exercise and antihypertensive therapy in hypertensive rats with chronic renal failure
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DOI：
10.1097/00004872-200110000-00024
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发表时间：
2001-10-01
影响因子：
4.9
通讯作者：
Yoshida, K
中科院分区：
文献类型：
--
作者：
Kohzuki, M;Kamimoto, M;Yoshida, K
目的慢性肾功能衰竭患者的活动受限于轻度体力活动，且往往缺乏运动。然而，关于慢性运动对肾脏疾病进展的影响的报道很少。同样，很少有动物模型关注运动训练对改善肾功能的影响。因此，我们评估了中度慢性跑台运动对慢性肾功能衰竭自发性高血压大鼠（SHR）残肾模型的肾脏影响。我们还评估了运动和抗高血压治疗对肾功能的影响。设计和方法8周龄的SHR进行5/6肾切除术切除左肾和切除三分之二的右肾。将大鼠分为四组：（i）不运动（Non-EX）;（ii）中度运动，跑步机跑步（20 m/min，0级倾斜60 min）（EX）;（iii）EX与血管紧张素转换酶（ACE）抑制剂依那普利（2 mg/kg/天，i. p.）;和（iv）EX与血管紧张素受体拮抗剂氯沙坦（5 mg/kg/天，i. p.），结果慢性EX能显著降低蛋白尿的增加（P < 0.01），并能显著降低肾小球硬化指数（OGS）的增加。依那普利和氯沙坦与EX联用均能显著降低血压（P < 0.001），并进一步降低IGS。多元逐步回归分析中，只有降压药是IGS的显著预测因素（P < 0.0001）。而运动、降压药物和平均收缩压（1-4周）仍是模型中平均蛋白尿（1 - 4周）的显著预测因子（P均< 0.0001）。结论运动对大鼠肾功能无明显损害，具有肾脏保护作用。此外，抗高血压治疗在该大鼠模型中具有额外的肾脏保护作用。(C)2001年利平科特威廉姆斯&威尔金斯。
Objectives Patients with chronic renal failure are restricted to mild physical activity and tend to a lack of exercise. However, there have been few reports regarding the influence of chronic exercise on the progression of renal disease. Similarly, there are few animal models concerned with the effect of exercise training on improving renal function. Therefore, we assessed the renal effects of moderate chronic treadmill exercise in a remnant kidney model of spontaneously hypertensive rats (SHR) with chronic renal failure. We also assessed the effects of exercise and antihypertensive therapy on renal function.Design and methods Eight-week-old SHR were subjected to 5/6 nephrectomy by removal of the left kidney and excision of two-thirds of the right kidney. The rats were divided into four groups: (i) no exercise (Non-EX); (ii) moderate exercise with treadmill running (20 m/min, 0 grade incline for 60 min) (EX); (iii) EX with an angiotensin converting enzyme (ACE) inhibitor, enalapril (2 mg/kg per day, i.p.); and (iv) EX with an angiotensin receptor antagonist, losartan (5 mg/kg per day, i.p.), for 4 weeks.Results Chronic EX significantly attenuated the increase in proteinuria (P < 0.01) and significantly protected against increases in the index of glomerular sclerosis OGS). Both enalapril and losartan with EX significantly decreased blood pressure (P < 0.001), and further decreased the IGS. In the stepwise multiple regression analysis, only antihypertensive drug remained in the model as a significant predictor of IGS (P < 0.0001). In contrast, exercise, antihypertensive drug and mean systolic blood pressure (weeks 1-4) remained in the model as a significant predictors of mean proteinuria (weeks 1-4) (all P < 0.0001).Conclusions These results suggest that exercise does not worsen renal function and has renal-protective effects in this model of rats. Moreover, the antihypertensive therapy has additional renal-protective effects in this model of rats. (C) 2001 Lippincott Williams & Wilkins.