The Prognostic Value of the Proportion and Architectural Patterns of Intraductal Carcinoma of the Prostate in Patients with De Novo Metastatic Prostate Cancer
The Prognostic Value of the Proportion and Architectural Patterns of Intraductal Carcinoma of the Prostate in Patients with De Novo Metastatic Prostate Cancer
复制标题
新发转移性前列腺癌患者中前列腺导管内癌的比例和结构模式的预后价值
DOI：
10.1016/j.juro.2018.10.016
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发表时间：
2019-04-01
影响因子：
6.6
通讯作者：
Zeng, Hao
中科院分区：
文献类型：
--
作者：
Zhao, Jinge;Liu, Jiandong;Zeng, Hao
目的：前列腺导管内癌是前列腺癌的一个不利因素。然而，导管内前列腺癌的比例和结构模式在患者outcome.Materials和方法中的作用仍不清楚：我们回顾性分析了2010年至2017年期间644例原发转移性前列腺癌患者的数据。前列腺导管内癌是从12芯前列腺活检中确定的。我们计算了导管内前列腺癌的比例，并根据2016年WHO分类确定了模式。进行倾向评分匹配，以平衡导管内前列腺癌和非导管内前列腺癌患者之间的基线特征。Kaplan-Meier曲线和考克斯回归用于生存分析。结果：在644例患者中，180例（28.0%）患有前列腺导管内癌。10%或更高的癌发生率与预后差独立相关（去势抵抗性前列腺癌无瘤生存率HR 2.06，95%CI 1.51-2.81，p
Purpose:Intraductal carcinoma of the prostate is an adverse prognosticator of prostate cancer. However, the roles of proportion and architectural patterns of intraductal prostate carcinoma in patient outcomes remain unclear.Materials and Methods:We retrospectively analyzed data on 644 patients with de novo metastatic prostate cancer between 2010 and 2017. Intraductal carcinoma of the prostate was identified from 12-core prostate biopsy. We calculated the proportion of intraductal prostate carcinoma and identified patterns according to the 2016 WHO classification. Propensity score matching was performed to balance baseline characteristics between patients with and without intraductal prostate carcinoma. Kaplan-Meier curves and Cox regression were used for survival analyses. The end points were castration resistant prostate cancer-free survival and overall survival.Results:Of the 644 patients 180 (28.0%) harbored intraductal carcinoma of the prostate. A 10% or greater incidence of the carcinoma was independently associated with worse prognosis (castration resistant prostate cancer-free survival HR 2.06, 95% CI 1.51-2.81, p