Inhibition of Amino Acid Incorporation in vitro by Metabolites of 2-Acetylaminofluorene and by Certain Nitroso Compounds.∗
Inhibition of Amino Acid Incorporation in vitro by Metabolites of 2-Acetylaminofluorene and by Certain Nitroso Compounds.∗
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2-乙酰氨基芴代谢物和某些亚硝基化合物在体外抑制氨基酸掺入。*
DOI：
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发表时间：
1965
期刊：
影响因子：
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通讯作者：
J. Miller
中科院分区：
文献类型：
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作者：
E. Miller;Diane McKechnie;Miriam M. Poirier;J. Miller
Summary 2-Nitrosofluorene, 2-nitrosotolu-ene, and nitrosobenzene, at concentrations of 5 × 10-5 M or greater inhibited the incorporation of amino acids into protein by a rat liver microsome-pH 5 fraction system. 2-Acetylaminofluorene, 2-aminofluorene, the N-hydroxy derivatives of these compounds, and the 1-, 3-, 5-, and 7-hydroxy derivatives of 2-acetylaminofluorene had little effect on amino acid incorporation at these levels. Repeated subcutaneous injections of 2-nitroso-fluorene into female rats induced moderate incidences of mammary carcinomas and of sarcomas at the injection site by 8 months. Similar injections of nitrosobenzene or of 2-nitrosotoluene were not carcinogenic.
