Monolayer-protected Au cluster (MPC)-supported Ti-BINOLate complex
Monolayer-protected Au cluster (MPC)-supported Ti-BINOLate complex
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DOI：
10.1021/ol035706n
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发表时间：
2003-11-13
期刊：
影响因子：
5.2
通讯作者：
Sasai, H
中科院分区：
文献类型：
--
作者：
Marubayashi, K;Takizawa, S;Sasai, H
在Au团簇表面成功地引入了两端带有（R）-1，1 '-联-2-萘酚（（R）-BINOL）结构的二硫化物。由所得单层保护的Au簇（MPC）生成的Ti-BINOL配合物促进了苯甲醛与Et 2 Zn的催化不对称烷基化反应，得到加合物，产率高达98%，ee为86%。反应完成后，BINOL官能化的MPC很容易回收。
Disulfides bearing (R)-1,1'-bi-2-naphthol ((R)-BINOL) moieties at each terminal position have been successfully introduced on the surface of Au cluster. Ti-BINOLate complex generated from the obtained monolayer-protected Au cluster (MPC) promoted catalytic asymmetric alkylation of benzaldehyde with Et2Zn to afford the adduct in up to 98% yield with 86% ee. After completion of the reaction, the BINOL-functionalized MPC was easily recovered.