3-p-Toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran and 2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran do not act as surfactants or micelles when inhibiting the aggregation of β-amyloid peptide
3-p-Toluoyl-2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran and 2-[4′-(3-diethylaminopropoxy)-phenyl]-benzofuran do not act as surfactants or micelles when inhibiting the aggregation of β-amyloid peptide
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DOI：
10.1016/s0960-894x(00)00645-4
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发表时间：
2001-01-22
影响因子：
2.7
通讯作者：
Twyman, LJ
中科院分区：
文献类型：
--
作者：
Allsop, D;Gibson, G;Twyman, LJ
测定了β-淀粉样蛋白（A β）聚集抑制剂3-对甲苯酰基-2-[4 ′-（3-二乙基氨基丙氧基）-苯基]-苯并呋喃1和2-[4 ′-（3-二乙基氨基丙氧基）-苯基]-苯并呋喃2的cmc和IC 50值。比较cmc数据和生物学数据（IC 50值）后，我们得出结论，这些活性苯并呋喃在抑制β-淀粉样肽聚集所需的浓度下不起表面活性剂或胶束的作用。(C)2001爱思唯尔科技有限公司版权所有。
The cmc and IC50 values of the beta -amyloid (A beta) aggregation inhibitors, 3-p-toluoyl-2-[4'-(3-diethylaminopropoxy)- phenyl]-benzofuran 1, and 2-[4'-(3-diethylaminopropoxy)-phenyl]-benzofuran 2 have been determined. After comparison of the cmc data and biological data (IC50 values), we conclude that these active benzofurans do not act as surfactants or micelles at the concentration required to inhibit beta -amyloid-peptide aggregation. (C) 2001 Elsevier Science Ltd. All rights reserved.