REGIONAL GLUCOSE METABOLIC CHANGES AFTER LEARNING A COMPLEX VISUOSPATIAL MOTOR TASK - A POSITRON EMISSION TOMOGRAPHIC STUDY
REGIONAL GLUCOSE METABOLIC CHANGES AFTER LEARNING A COMPLEX VISUOSPATIAL MOTOR TASK - A POSITRON EMISSION TOMOGRAPHIC STUDY
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DOI：
10.1016/0006-8993(92)90573-r
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发表时间：
1992-01-20
期刊：
影响因子：
2.9
通讯作者：
BUCHSBAUM, MS
中科院分区：
文献类型：
--
作者：
HAIER, RJ;SIEGEL, BV;BUCHSBAUM, MS
8名年轻男性在练习前和练习后进行复杂的视觉空间/运动任务（电脑游戏俄罗斯方块），用正电子发射断层扫描（PET）和18-氟-2-脱氧葡萄糖（FDG）定量测定两次局部脑葡萄糖代谢率（GMR）。 在每天练习俄罗斯方块4-8周后，皮质表面区域的GMR下降，尽管表现增加了7倍以上。 在练习后提高俄罗斯方块表现最多的受试者在几个领域的练习后显示出最大的葡萄糖代谢下降。 这些结果表明，学习可能会导致减少使用无关或低效的大脑区域。 区域皮质下葡萄糖代谢率的变化与实践可能反映了认知策略的变化，是学习过程的一部分。
Regional cerebral glucose metabolic rate (GMR) quantified with positron emission tomography (PET) with 18-fluoro-2-deoxyglucose (FDG) was measured twice in 8 young men performing a complex visuospatial/motor task (the computer game Tetris), before and after practice. After 4-8 weeks of daily practice on Tetris, GMR in cortical surface regions decreased despite a more than 7-fold increase in performance. Subjects who improved their Tetris performance the most after practice showed the largest glucose metabolic decreases after practice in several areas. These results suggest that learning may result in decreased use of extraneous or inefficient brain areas. Changes in regional subcortical glucose metabolic rate with practice may reflect changes in cognitive strategy that are a part of the learning process.