The role myeloid dendritic cells play in the pathogenesis of systemic lupus erythematosus
The role myeloid dendritic cells play in the pathogenesis of systemic lupus erythematosus
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DOI：
10.1016/j.autrev.2007.01.014
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发表时间：
2007-08-01
影响因子：
13.6
通讯作者：
Alcocer-Varela, Jorge
中科院分区：
文献类型：
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作者：
Crispin, Jose C.;Alcocer-Varela, Jorge
树突状细胞（DC）在免疫应答的发展和外周耐受的维持中起关键作用。它们不断地巡视组织并采集抗原样本，以寻找炎症或病原体衍生信号的存在;它们根据环境中普遍存在的信号成熟，并通过这样做获得某些特征，使它们能够向它们将在局部淋巴结内遇到的T细胞传达精确的信息-无论是生产性的还是调节性的。有证据表明DC参与了SLE的发病机制。它们诱导抗核导向的自身免疫反应的能力已在动物模型中得到证实。此外，它们的成熟过程是异常的，并且它们的细胞因子分泌和T细胞刺激在SLE患者中是偏向的。然而，狼疮是一个有问题的环境，他们的研究和表征。SLE患者的血清中含有几种能够诱导DC表型和功能变化的因子。因此，已报告的异常可能代表DC内在缺陷，由于异常环境导致的偏斜表型，或两者的组合。在这篇综述中，我们讨论了现有的信息，试图调和这些问题。(c)2007 Elsevier B. V.保留所有权利。
Dendritic cells (DC) play a pivotal role in the development of immune responses and the maintenance of peripheral tolerance. They continuously patrol tissues and sample antigens in search for the presence of inflammatory or pathogen-derived signals; they mature in accordance to signs prevalent in their environment and, by doing so, acquire certain features that will allow them to convey a precise message - either productive or regulatory - to the T cells they will encounter within regional lymph nodes. Evidence suggests that DC are involved in the pathogenesis of SLE. Their capacity to induce an antinuclear-oriented autoimmune response has been proven in animal models. Further, their maturation process is abnormal and their cytokine secretion and T cell stimulation is biased in patients with SLE. Lupus, however, is a problematic environment for their study and characterization. Sera from SLE patients contain several factors capable of inducing phenotypic and functional changes in DC. Thus, the abnormalities that have been reported may represent DC-intrinsic defects, a skewed phenotype due to an abnormal milieu, or a combination of both. In this review we discuss the available information in an attempt to reconcile these issues. (c) 2007 Elsevier B.V. All rights reserved.