A Case of Antiepiligrin Cicatricial Pemphigoid with Nephrotic Syndrome
A Case of Antiepiligrin Cicatricial Pemphigoid with Nephrotic Syndrome
复制标题
抗癫痫药瘢痕性类天疱疮合并肾病综合征一例
DOI：
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
T. Kanzaki
中科院分区：
文献类型：
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作者：
Y. Uchino;T. Kanekura;K. Takeda;Hidehiko Shimada;M. Inoue;T. Hashimoto;T. Kanzaki
我们报告一位71岁女性抗癫痫剂疤痕性类天疱疮合并肾病综合征。她的躯干和腿部有六个月的湿疹水泡病史。她也有反复发作的疼痛性口腔糜烂。皮肤活检显示表皮下大疱，直接免疫荧光（DIF）研究显示IgG和C3在基底膜区（BMZ）的线性沉积。1 M NaCl-分裂皮肤的间接免疫荧光（IIF）染色显示循环IgG自身抗体与真皮侧反应。对患者血清的免疫沉淀研究揭示了针对一组对应于层粘连蛋白5（β3γ2）的多肽的IgG自身抗体。基于她的腿部长期水肿和低蛋白血症，她被诊断为肾病综合征。据我们所知，抗癫痫素与瘢痕性类天疱疮和肾病综合征的关系以前未见报道。
We report a 71‐year‐old woman with antiepiligrin cicatricial pemphigoid associated with nephrotic syndrome. She presented with a six‐month history of pruritic blisters over her trunk and legs. She also had episodes of recurrent painful oral erosions. A skin biopsy showed a subepidermal bulla, and a direct immunofluorescence (DIF) study revealed linear deposition of IgG and C3 at the basement membrane zone (BMZ). Indirect immunofluorescence (IIF) staining of 1 M NaCl‐split skin demonstrated circulating IgG autoantibodies reactive with the dermal side. Immunoprecipitation studies of the patient's serum disclosed IgG autoantibodies directed against a set of polypeptides that corresponded to laminin 5 (β3γ2). Based upon the long‐standing edema of her legs and her hypoproteinemia, she was diagnosed with nephrotic syndrome. To our knowledge, the association of antiepiligrin cicatricial pemphigoid with nephrotic syndrome has not been reported previously.
影响因子：
6.5
作者：
KIRTSCHIG, G;MARINKOVICH, MP;YANCEY, KB
通讯作者：
YANCEY, KB