Chemically Programmed Antibodies AS HIV-1 Attachment Inhibitors.
Chemically Programmed Antibodies AS HIV-1 Attachment Inhibitors.
复制标题
DOI：
10.1021/ml400097z
复制
发表时间：
2013-05-09
影响因子：
4.2
通讯作者：
Barbas CF 3rd
中科院分区：
文献类型：
--
作者：
Sato S;Inokuma T;Otsubo N;Burton DR;Barbas CF 3rd
Herein we describe the design and application of two small-molecule anti-HIV compounds for the creation of chemically programmed antibodies. N-acyl-β-lactam derivatives of two previously described molecules BMS-378806 and BMS-488043 that inhibit the interaction between HIV-1 gp120 and T-cells were synthesized and used to program the binding activity of aldolase antibody 38C2. Discovery of a successful linkage site to BMS-488043 allowed for the synthesis of chemically programmed antibodies with affinity for HIV-1 gp120 and potent HIV-1 neutralization activity. Derivation of a successful conjugation strategy for this family of HIV-1 entry inhibitors enables its application in chemically programmed antibodies and vaccines and may facilitate the development of novel bispecific antibodies and topical microbicides.
登录
查看更多内容
影响因子：
2.7
作者：
Meanwell, Nicholas A.;Wallace, Owen B.;Lin, Pin-Fang
通讯作者：
Lin, Pin-Fang
影响因子：
7.3
作者：
Regueiro-Ren, Alicia;Xue, Qiufen M.;Kadow, John F.
通讯作者：
Kadow, John F.
DOI：
10.1073/pnas.96.12.6925
发表时间：
1999-06-08
影响因子：
11.1
作者：
Shabat, D;Rader, C;Barbas, CF
通讯作者：
Barbas, CF
DOI：
10.1126/science.1213256
发表时间：
2011-11-25
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Pejchal R;Doores KJ;Walker LM;Khayat R;Huang PS;Wang SK;Stanfield RL;Julien JP;Ramos A;Crispin M;Depetris R;Katpally U;Marozsan A;Cupo A;Maloveste S;Liu Y;McBride R;Ito Y;Sanders RW;Ogohara C;Paulson JC;Feizi T;Scanlan CN;Wong CH;Moore JP;Olson WC;Ward AB;Poignard P;Schief WR;Burton DR;Wilson IA
通讯作者：
Wilson IA
影响因子：
5.4
作者：
Guo, Q;Ho, HT;Lin, PF
通讯作者：
Lin, PF