Single nucleotide polymorphisms in cholesteryl ester transfer protein gene and recurrent coronary heart disease or mortality in patients with established atherosclerosis.
Single nucleotide polymorphisms in cholesteryl ester transfer protein gene and recurrent coronary heart disease or mortality in patients with established atherosclerosis.
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胆固醇酯转移蛋白基因的单核苷酸多态性与动脉粥样硬化患者的复发性冠心病或死亡率。
DOI：
10.1016/j.amjcard.2013.05.073
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Ballantyne,ChristieM
中科院分区：
文献类型：
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作者：
Virani,SalimS;Lee,Vei-Vei;Brautbar,Ariel;Grove,MeganL;Nambi,Vijay;Alam,Mahboob;Elayda,MacArthur;Wilson,JamesM;Willerson,JamesT;Boerwinkle,Eric;Ballantyne,ChristieM
目前尚不清楚胆固醇酯转移蛋白（CETP）基因的遗传变异是否与二级预防患者的复发性冠心病事件或死亡率相关。在3,717例急性冠状动脉综合征或冠状动脉旁路移植术（CABG）患者中，我们评估了CETP基因变异是否与CETP活性降低和高密度脂蛋白胆固醇升高相关（TaqIB [rs708272]和rs 12149545的“A”等位基因）与复发性心肌梗死（MI）、复发性血管重建或死亡的减少相关。在4.5年的随访中，发生了439例复发性MI、698例复发性血运重建和756例死亡。使用加性遗传模型，rs708272的“A”等位基因与MI复发无关（AG的风险比[HR] 0.95，95%置信区间[CI] 0.78至1.17; AA的风险比[HR] 0.89，95% CI 0.67至1.19;与GG基因型相比）、复发性血运重建（AG的HR 1.13，95% CI 0.95 - 1.33; AA的HR 1.05，95% CI 0.84 - 1.32）或死亡（AG的HR 1.02，95% CI 0.86 - 1.19; AA的HR 1.11，95% CI 0.91 - 1.37）。对于rs 12149545的“A”等位基因也观察到类似的结果。在CABG亚组中，与GG基因型相比，rs708272 AG基因型与死亡率增加相关（HR 1.38，95% CI 1.06至1.79）。结果保持一致，使用显性遗传模型。总之，在接受CABG的患者中，遗传CETP变异与整个队列中的复发性MI或复发性血运重建无关，可能增加死亡率。
It is not known whether genetic variants in the cholesteryl ester transfer protein (CETP) gene are associated with recurrent coronary heart disease events or mortality in secondary prevention patients. Among 3,717 patients with acute coronary syndrome or coronary artery bypass grafting (CABG) enrolled in a prospective genetic registry, we evaluated whether CETP gene variants previously shown to be associated with reduced CETP activity and high-density lipoprotein cholesterol increase (“A” allele for bothTaqIB [rs708272] and rs12149545) are associated with a reduction in recurrent myocardial infarction (MI), recurrent revascularization, or death. At 4.5 years of follow-up, 439 recurrent MI, 698 recurrent revascularizations, and 756 deaths occurred. Using an additive model of inheritance, the “A” allele for rs708272 was not associated with recurrent MI (hazard ratio [HR] 0.95, 95% confidence interval [CI] 0.78 to 1.17 for AG; HR 0.89, 95% CI 0.67 to 1.19 for AA; compared with GG genotype), recurrent revascularization (HR 1.13, 95% CI 0.95 to 1.33 for AG; HR 1.05, 95% CI 0.84 to 1.32 for AA), or mortality (HR 1.02, 95% CI 0.86 to 1.19 for AG; HR 1.11, 95% CI 0.91 to 1.37 for AA) in the overall cohort. Similar results were seen for the “A” allele for rs12149545. In the CABG subgroup, AG genotype for rs708272 was associated with an increased mortality (HR 1.38, 95% CI 1.06 to 1.79) compared with GG genotype. Results remained consistent using dominant model of inheritance. In conclusion, genetic CETP variants were not associated with recurrent MI or recurrent revascularization in overall cohort with a possible mortality increase in patients who underwent CABG.