PLASMA FLUORIDE LEVELS AND ENAMEL FLUOROSIS IN THE RAT
PLASMA FLUORIDE LEVELS AND ENAMEL FLUOROSIS IN THE RAT
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DOI：
10.1159/000260617
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发表时间：
1982-01-01
期刊：
影响因子：
4.2
通讯作者：
WHITFORD, GM
中科院分区：
文献类型：
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作者：
ANGMARMANSSON, B;WHITFORD, GM
瞬时峰值血浆氟[F-]水平（s.c.注射）和较低但相对恒定的水平（s.c.恒定输注）和显微放射照相测定的大鼠切牙釉质矿化紊乱的发生。F-剂量给药1周，2周后处死动物。每天一次10 μ M的血浆F-峰值水平与釉质矿化的干扰一致相关，但每天一次5 μ M的峰值水平或每天两次5 μ M的峰值水平与釉质矿化的干扰无关。相对恒定的血浆F-水平（平均为3.3 μ M）与釉质形成变化的发生率增加有关，4.7 μ M的水平始终与釉质矿化的紊乱有关。大鼠是一个更好的模型，为研究人类釉质氟中毒比以前认为，和轻微升高，但相对恒定的血浆F-水平更可能与氟干扰的发生在矿化的釉质比罕见的高和短暂的峰值水平。
The relationship between transient peak plasma fluoride [F-] levels (s.c. injections) and lower but relatively constant levels (s.c. constant infusion) and the occurrence of disturbances in the enamel mineralization of the rat incisor as determined microradiographically was studied. The F- doses were administered for 1 wk and the animals were killed 2 wk later. Once-daily peak plasma F- levels of 10 .mu.M were uniformly associated with disturbances in the mineralization of the enamel, but once-daily peak levels of 5 .mu.M or twice-daily 5-.mu.M peaks were not. Relatively constant plasma F- levels, which averaged 3.3 .mu.M, were associated with an increased incidence of changes in enamel formation, and levels of 4.7 .mu.M consistently associated with disturbances in enamel mineralization. The rat was a better model for the study of human enamel fluorosis than previously believed, and slightly elevated but relatively constant plasma F- levels were more likely to be associated with the occurrence of fluorotic disturbances in the mineralization of enamel than were the rarer high and transient peak levels.