Age at onset is associated with the seasonal pattern of onset and exacerbation in inflammatory bowel disease
Age at onset is associated with the seasonal pattern of onset and exacerbation in inflammatory bowel disease
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DOI：
10.1007/s00535-017-1313-6
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发表时间：
2017-11-01
影响因子：
6.3
通讯作者：
Takehara, Tetsuo
中科院分区：
文献类型：
--
作者：
Araki, Manabu;Shinzaki, Shinichiro;Takehara, Tetsuo
环境因素被认为会影响包括炎症性肠病（IBD）在内的几种疾病的发病机制。然而，IBD发病和恶化的季节性尚不明确。我们在此旨在阐明疾病的季节性，并调查IBD患者的基本特征，表现出季节性的疾病course.This是一个多中心的观察性研究，包括20个机构（大坂肠道论坛）在日本。从2013年11月至2014年8月，使用医生调查表和患者问卷收集数据。对1055例患者（包括298例克罗恩病（CD）和757例溃疡性结肠炎（UC）患者）进行多因素分析，以阐明影响疾病季节性的独立因素。CD患者夏季发病的比例明显高于其他季节，而UC患者发病无季节性。超过一半的IBD患者（51.1%）经历了IBD的季节性加重，冬季是CD和UC患者疾病加重的最常见季节。季节性疾病的发病和加重观察到，
Environmental factors are suggested to affect the pathogenesis of several diseases, including inflammatory bowel disease (IBD). The seasonality of disease onset and exacerbation in IBD, however, are not well established. We herein aimed to clarify the disease seasonality and to investigate the underlying characteristics in IBD patients exhibiting seasonality of the disease course.This was a multicenter observational study comprising 20 institutions (Osaka Gut Forum) in Japan. Data were collected from November 2013 to August 2014 using survey forms for physicians and questionnaires for patients. Multivariate analysis was performed to clarify the independent factors affecting disease seasonality.A total of 1055 patients, including 298 patients with Crohn's disease (CD) and 757 patients with ulcerative colitis (UC), were enrolled. The proportion of CD patients with disease onset in the summer was significantly larger than that in the other seasons, while UC patients exhibited no seasonality of disease onset. More than half of the IBD patients (51.1%) experienced seasonal exacerbation of IBD, and winter was the most common season for disease exacerbation in both CD and UC patients. Seasonality of disease onset and exacerbation was observed in young-onset patients (