Copper-Catalyzed Trifluoromethylation of Aryl Iodides with Potassium (Trifluoromethyl)trimethoxyborate
Copper-Catalyzed Trifluoromethylation of Aryl Iodides with Potassium (Trifluoromethyl)trimethoxyborate
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DOI：
10.1002/chem.201002749
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发表时间：
2011-02-01
影响因子：
4.3
通讯作者：
Goossen, Lukas J.
中科院分区：
文献类型：
--
作者：
Knauber, Thomas;Arikan, Fatih;Goossen, Lukas J.
介绍了三氟甲基三甲氧基硼酸钾作为铜催化三氟甲基化反应中CF 3亲核试剂的新来源。该结晶盐在储存时稳定，易于处理，并且可以简单地通过混合B（OMe）（3）、CF 3SiMe 3和KF以接近定量的产率获得。三氟甲基化试剂允许在温和的无碱条件下，在催化量的Cu-I/1，10-菲咯啉络合物存在下，以高产率将各种芳基碘转化为相应的苯并三氟。
Potassium (trifluoromethyl)trimethoxyborate is introduced as a new source of CF3 nucleophiles in copper-catalyzed trifluoromethylation reactions. The crystalline salt is stable on storage, easy to handle, and can be obtained in near-quantitative yields simply by mixing B(OMe)(3), CF3SiMe3, and KF. The trifluoromethylation reagent allows the conversion of various aryl iodides into the corresponding benzotrifluorides in high yields under mild, base-free conditions in the presence of catalytic quantities of a Cu-I/1,10-phenanthroline complex.