TWO-DIMENSIONAL GRAPHIC ANALYSIS OF DNA-SEQUENCE HOMOLOGIES
TWO-DIMENSIONAL GRAPHIC ANALYSIS OF DNA-SEQUENCE HOMOLOGIES
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DOI：
10.1093/nar/10.1.365
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发表时间：
1982-01-01
影响因子：
14.9
通讯作者：
GUSTAFSSON, P
中科院分区：
文献类型：
--
作者：
HARR, R;HAGBLOM, P;GUSTAFSSON, P
我们描述了一个计算机程序，旨在促进DNA序列之间的同源性的模式匹配分析。它利用二维图，以简化序列中遗传的重要结构的评估。该程序可分为三个部分，i）同源性搜索算法，ii）结果的二维图形显示，iii）进一步的图形处理以增强重要结构。图形显示的力量通过以下程序的应用来呈现。我们已经进行了小鼠免疫球蛋白K链基因的直接重复序列的搜索。在J4、J5区发现了一段较长的同源序列，表明存在重复DNA。
We describe a computer program designed to facilitate the pattern matching analysis of homologies between DNA sequences. It takes advantage of a two-dimensional plot in order to simplify the evaluation of significant structures inherited in the sequences. The program can be divided into three parts, i) algorithm for search of homologies, ii) twodimensional graphic display of the result, iii) further graphic treatment to enhance significant structures.The power of the graphic display is presented by the following application of the program. We have conducted a search for direct repeats in the mouse immunoglobulin K-chain genes. Both the five J DNA sequences and other shorter repeats were found. We also found a longer stretch of homology that could indicate the presence of duplicated DNA in the J4, J5 region.