Biomedical aspects of targeted delivery of drugs to pulmonary endothelium.
Biomedical aspects of targeted delivery of drugs to pulmonary endothelium.
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DOI：
10.1517/17425247.2.5.909
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发表时间：
2005-09-01
影响因子：
6.6
通讯作者：
Muzykantov, Vladimir R
中科院分区：
文献类型：
--
作者：
Muzykantov, Vladimir R
药物靶向肺内皮细胞的选定亚细胞区室可以优化许多疾病的治疗。本文介绍了内皮细胞的决定因素，是潜在的有用的，这样的目标，包括内皮细胞外肽酶，细胞粘附分子和新的候选人确定的高通量方法，以及手段，以实现最佳的亚细胞靶向药物在内皮细胞，已在细胞培养和动物研究中进行了探索。确定靶向适用性的标准包括可及性、特异性、安全性和亚细胞精确度。治疗剂的内皮递送的影响，包括通过干预靶决定因素的功能介导的影响，必须在给定的病理条件下进行表征。
Drug targeting to selected subcellular compartments of the pulmonary endothelium may optimise treatment of many diseases. This paper describes endothelial determinants that are potentially useful for such targeting, including endothelial ectopeptidases, cell adhesion molecules and novel candidates identified by high-throughput methods, as well as the means to achieve optimal subcellular targeting of drugs in the endothelium that have been explored in cell culture and animal studies. Criteria for determining the applicability for targeting include accessibility, specificity, safety and subcellular precision. The effects of endothelial delivery of therapeutic agents, including the effects mediated by the intervention in the function of the target determinants, must be characterised in the context of given pathological conditions.