Functional responses of estrogen receptors in the male and female auditory system
Functional responses of estrogen receptors in the male and female auditory system
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DOI：
10.1016/j.heares.2008.12.009
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发表时间：
2009-06-08
期刊：
影响因子：
2.8
通讯作者：
Canlon, Barbara
中科院分区：
文献类型：
--
作者：
Charitidi, Konstantina;Meltser, Inna;Canlon, Barbara
最近，在理解两种雌激素受体(α和β)在不同组织中参与雌激素作用的不同途径的机制方面取得了重大进展。细胞和组织对雌激素或其配体的不同反应归因于雌激素受体的不同亚型和信号通路。这两种雌激素受体的亚型都已在耳蜗中被发现，并有迹象表明它们具有神经保护作用，但关于这两种受体在听觉系统中的作用和具体机制的信息仍然有限。本文将对这两种雌激素受体亚型的分子和功能作用、它们在听觉系统中的关键作用以及它们预防听力损失的治疗策略进行综述。(C)2009爱思唯尔B.V.保留所有权利。
Recently significant progress was made in understanding the mechanisms by which the two estrogen receptors (alpha and beta) are involved in different pathways of estrogen action in a wide variance of tissues. Divergent responses of cells and tissues to estrogens or their ligands have been attributed to various isoforms and signaling pathways of estrogen receptors. Both subtypes of estrogen receptors have been identified in the cochlea and there are indications that they have neuroprotective effects but there is still limited information on the role and specific mechanisms of these two receptors in the auditory system. This review will examine the molecular and functional actions of the two estrogen receptor subtypes, the pivotal role they play in the auditory system and their therapeutic strategies for protecting against hearing loss. (C) 2009 Elsevier B.V. All rights reserved.