The genomic sequence of the accidental pathogen Legionella pneumophila
The genomic sequence of the accidental pathogen Legionella pneumophila
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DOI：
10.1126/science.1099776
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发表时间：
2004-09-24
期刊：
影响因子：
56.9
通讯作者：
Russo, JJ
中科院分区：
文献类型：
--
作者：
Chien, MC;Morozova, I;Russo, JJ
我们介绍了嗜肺军团菌的基因组序列，这种细菌是军团病的病原体，是一种从雾化污染的淡水中获得的潜在致命肺炎。基因组包括一对45kb的元件，它可以以染色体和上体的形式存在，重要基因家族的选择性扩展，意外代谢途径的基因，以及以前未知的候选毒力决定因素。我们强调可能解释军团菌在原生动物、哺乳动物巨噬细胞和不适宜居住的环境中生存的能力的基因，并可能定义新的治疗靶点。
We present the genomic sequence of Legionella pneumophila, the bacteria[ agent of Legionnaires' disease, a potentially fatal pneumonia acquired from aerosolized contaminated fresh water. The genome includes a 45-kilobase pair element that can exist in chromosomal and episomal forms, selective expansions of important gene families, genes for unexpected metabolic pathways, and previously unknown candidate virulence determinants. We highlight the genes that may account for Legionella's ability to survive in protozoa, mammalian macrophages, and inhospitable environmental niches and that may define new therapeutic targets.