Periconceptional undernutrition in sheep accelerates maturation of the fetal hypothalamic-pituitary-adrenal axis in late gestation
Periconceptional undernutrition in sheep accelerates maturation of the fetal hypothalamic-pituitary-adrenal axis in late gestation
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DOI：
10.1210/en.2004-0424
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发表时间：
2004-09-01
期刊：
影响因子：
4.8
通讯作者：
Challis, JRG
中科院分区：
文献类型：
--
作者：
Bloomfield, FH;Oliver, MH;Challis, JRG
我们研究了交配前60天至交配后30天母体中度围产期营养不良对妊娠晚期胎儿下丘脑-垂体-肾上腺轴功能的影响。在营养不良期间定期对母羊进行采样，以测定循环激素水平。在妊娠112 d（足月，145 d）时将血管导管插入母羊及其单胎胎儿，并在127和128 d进行胎儿ACTH（1-24）和甲吡酮激发试验。在132 d时进行尸检。与自由采食母羊（n = 10）的胎儿相比，营养不良母羊（UN，n = 12）的胎儿基线皮质醇浓度升高（P < 0.05）。两组胎儿对ACTH刺激的反应没有差异，但只有UN胎儿对甲吡酮表现出ACTH和11-脱氧皮质醇反应（P
We investigated the effects of moderate maternal periconceptional undernutrition from 60 d before to 30 d after mating on fetal hypothalamic-pituitary-adrenal axis function in late gestation. Ewes were sampled regularly during the period of undernutrition for circulating hormone levels. Vascular catheters were inserted into ewes and their singleton fetuses at 112 d gestation (term, 145 d), and fetal ACTH(1-24) and metyrapone challenge tests were performed at 127 and 128 d. Postmortems were performed at 132 d. Fetuses of undernourished ewes (UN, n = 12) had elevated baseline cortisol concentrations (P < 0.05), compared with fetuses of ad libitum-fed ewes (n = 10). There were no differences between groups in fetal responses to ACTH challenge, but only UN fetuses demonstrated ACTH and 11-deoxycortisol responses to metyrapone (P