Suppressor of fused (Sufu) represses Gli1 transcription and nuclear accumulation, inhibits glioma cell proliferation, invasion and vasculogenic mimicry, improving glioma chemo-sensitivity and prognosis.
Suppressor of fused (Sufu) represses Gli1 transcription and nuclear accumulation, inhibits glioma cell proliferation, invasion and vasculogenic mimicry, improving glioma chemo-sensitivity and prognosis.
复制标题
融合抑制剂 (Sufu) 抑制 Gli1 转录和核积累，抑制神经胶质瘤细胞增殖、侵袭和血管生成拟态，改善神经胶质瘤化疗敏感性和预后
DOI：
10.18632/oncotarget.2585
复制
发表时间：
2014-11-30
期刊：
影响因子：
--
通讯作者：
Jiang C
中科院分区：
文献类型：
--
作者：
Liu X;Wang X;Du W;Chen L;Wang G;Cui Y;Liu Y;Dou Z;Wang H;Zhang P;Chang L;Yi L;Cai J;Jiang C
胶质母细胞瘤是高度侵袭性的脑肿瘤，预后差。虽然已经描述了神经胶质瘤中信号通路的各种失调，但生物标志物和治疗靶点的鉴定仍然是新的诊断和治疗方法的重要任务。在这里，我们描述了融合的抑制因子（也称为Sufu）在高级别胶质瘤中显著下调，与预后不良相关。我们证明了Sufu的异位表达抑制了细胞增殖、侵袭和血管生成拟态。此外，过表达的Sufu降低Gli报告基因的转录活性，并防止Gli1核积累，而敲低Sufu逆转这些影响。此外，过表达的Sufu使胶质母细胞瘤对替莫唑胺和环巴胺敏感。因此，腐乳是胶质母细胞瘤潜在的抑瘤剂和治疗靶点。
Glioblastoma are highly aggressive brain tumors with poor prognosis. While various dysregulation of signaling pathways in gliomas have been described, the identification of biomarkers and therapy targets remains an important task for novel diagnostic and therapeutic approaches. Here we described that the Suppressor of fused (also known as Sufu) is significantly down-regulated in high-grade gliomas, correlating with a poor prognosis. We demonstrated that ectopic expression of Sufu inhibited cell proliferation, invasion and vasculogenic mimicry. In addition, overexpression of Sufu reduced Gli reporter gene transcription activity and prevented Gli1 nuclear accumulation, whereas knockdown of Sufu reversed these effects. Furthermore, overexpressed Sufu sensitized glioblastoma to Temozolomide and Cyclopamine. Thus, Sufu is potential tumor suppressor and therapeutic target in glioblastoma.
登录
查看更多内容
DOI：
10.1107/s0907444913028473
发表时间：
2013-12
期刊：
Acta crystallographica. Section D, Biological crystallography
影响因子：
--
作者：
Cherry AL;Finta C;Karlström M;Jin Q;Schwend T;Astorga-Wells J;Zubarev RA;Del Campo M;Criswell AR;de Sanctis D;Jovine L;Toftgård R
通讯作者：
Toftgård R
影响因子：
4.7
作者：
Liao, Xiaoyun;Siu, Michelle K. Y.;Cheung, Annie N. Y.
通讯作者：
Cheung, Annie N. Y.
影响因子：
4.3
作者：
Blagosklonny, MV
通讯作者：
Blagosklonny, MV
影响因子：
158.5
作者：
Hegi, ME;Diserens, A;Stupp, R
通讯作者：
Stupp, R
DOI：
10.1073/pnas.0706901104
发表时间：
2007-12-18
影响因子：
11.1
作者：
Lee, Daniel Y.;Deng, Zhaoqun;Yang, Burton B.
通讯作者：
Yang, Burton B.