Cocrystal production method reducing deposition risk of undesired single component crystals in anti-solvent cocrystallization
Cocrystal production method reducing deposition risk of undesired single component crystals in anti-solvent cocrystallization
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DOI：
10.1016/j.jiec.2016.01.027
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发表时间：
2016-04-25
影响因子：
6.1
通讯作者：
Takiyama, Hiroshi
中科院分区：
文献类型：
--
作者：
Nishimaru, Momoko;Kudo, Shoji;Takiyama, Hiroshi
共结晶操作存在沉积不需要的晶体的风险。在本研究中，研究了考虑降低不良单组分晶体沉积风险的共晶生产方法策略。在卡马西平(CBZ)、糖精(SAC)、甲醇和水四组分体系中进行反溶剂共结晶。根据溶液添加顺序，不需要的单组分晶体会沉淀。考虑到每个组分的驱动力，在相图上确定了没有不需要的晶体沉积风险的域。为了生产所需的共晶体，将操作点保持在该范围内非常重要。 (C) 2016 年韩国产业工程化学学会。由 Elsevier B.V. 出版。保留所有权利。
The cocrystallization operation has the deposition risk of undesired crystals. In this study, the strategy of cocrystal production method considering the risk reduction of undesired single component crystal deposition was investigated. The anti-solvent cocrystallization was carried out in four-component system of carbamazepine (CBZ), saccharin (SAC), methanol and water. The undesired single component crystals precipitated depending on the solution addition sequences. Considering the driving force for each component, a domain without the deposition risk of the undesired crystals was determined on the phase diagram. It is important to keep the operation point in this domain for production of desired cocrystals. (C) 2016 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.