Regulatory network of genes associated with stimuli sensing, signal transduction and physiological transformation of appressorium in Magnaporthe oryzae.
Regulatory network of genes associated with stimuli sensing, signal transduction and physiological transformation of appressorium in Magnaporthe oryzae.
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与 Magnaporthe oryzae 的刺激感知、信号转导和附着细胞生理转化相关的基因调控网络。
DOI：
10.1080/21501203.2018.1492981
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Wang Z
中科院分区：
文献类型：
--
作者：
Anjago WM;Zhou T;Zhang H;Shi M;Yang T;Zheng H;Wang Z
由稻瘟病菌引起的稻瘟病是影响水稻生产的最具破坏性的病害，全球平均每年损失10-30%。最近的报道表明，该真菌还能引起小麦(Triticum Aestivum)的稻瘟病，严重威胁小麦生产。由于其易于检测的感染过程和可操纵的遗传操作，米曲霉被认为是探索病原-寄主相互作用中真菌致病的分子机制的模式生物。米曲霉利用一种称为附着胞的感染结构，通过产生高膨胀压力来突破寄主表面。附着胞的发育是由高度保守的cAMP/PKA、MAPK和钙信号通路协调的物理和化学信号诱导的。与附着胞发育相关的基因已经在水稻根结线虫中得到了鉴定和研究，目前还需要对附着胞的刺激传感和生理转化的工作基因网络进行总结。本文对附着胞发育的调控网络进行了全面的讨论，重点介绍了附着胞诱导刺激、信号转导、转录调控以及相应的发育和生理反应。我们还讨论了附着胞发育过程中各种途径的串扰和相互作用。
Rice blast caused by Magnaporthe oryzae is the most destructive disease affecting the rice production (Oryza sativa), with an average global loss of 10–30% per annum. Recent reports have indicated that the fungus also inflicts blast disease on wheat (Triticum aestivum) posing a serious threat to the wheat production. Due to its easily detected infectious process and manoeuvrable genetic manipulation, M. oryzae is considered a model organism for exploring the molecular mechanism underlying fungal pathogenicity during the pathogen–host interaction. M. oryzae utilises an infectious structure called appressorium to breach the host surface by generating high turgor pressure. The appressorium development is induced by physical and chemical cues which are coordinated by the highly conserved cAMP/PKA, MAPK and calcium signalling cascades. Genes involved in the appressorium development have been identified and well studied in M. oryzae, a summary of the working gene network linking stimuli sensing and physiological transformation of appressorium is needed. This review provides a comprehensive discussion regarding the regulatory networks underlying appressorium development with particular emphasis on sensing of appressorium inducing stimuli, signal transduction, transcriptional regulation and the corresponding developmental and physiological responses. We also discussed the crosstalk and interaction of various pathways during the appressorium development.