Effect of histamine on coronary microvascular permeability.
Effect of histamine on coronary microvascular permeability.
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组胺对冠状动脉微血管通透性的影响。
DOI：
10.1152/ajpheart.1984.247.1.h1
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
M. B. Maron
中科院分区：
文献类型：
--
作者：
C. F. Pilati;M. B. Maron
在自体血液灌注的犬心脏自动跳动时，在静脉压升高的条件下，观察组胺对冠状动脉血管通透性的影响。从脉管系统到间质过滤的液体表观体积（VF）通过血浆蛋白浓度的增加和红细胞压积的增加来计算。用蛋白滤过体积与红细胞压积滤过体积之比（VF,Pr/VF,Hct）来评价通透性的变化。在没有组胺的情况下，VF、Pr/VF、Hct接近一致（1.05 +/- 0.11），说明血蛋白和红细胞浓度相等。因此，漏出物基本上不含蛋白质。组胺（3.8 +/- 0.3 μ g碱基/ml血）处理后，VF、Pr/VF、Hct降至0.37 +/- 0.06 (P < 0.001)，表明冠状动脉血管通透性增加。该值在组胺暴露的60分钟内保持不变。组胺暴露后1 min主动脉灌注压由111 +/- 11显著降低至84 +/- 5 mmHg (P < 0.05)，随后缓慢升高。在7颗心脏中的4颗中，观察到左心室等容压发展（13-31 mmHg）和心率（4-29次/分钟）同时增加。在其余的心脏中，这两个变量都不受组胺的影响。我们得出的结论是，组胺导致犬冠状动脉微血管通透性增加，但未能持续增加心率或左心室功能。
The effect of histamine on coronary vascular permeability was assessed under conditions of elevated venous pressure in the spontaneously beating, isolated canine heart perfused with autologous blood. The apparent volume of fluid filtered from the vasculature to the interstitium (VF) was calculated from the increase in plasma protein concentration and also from the increase in hematocrit. The ratio of the protein-filtered volume to the hematocrit-filtered volume (VF,Pr/VF,Hct) was used to evaluate changes in permeability. In the absence of histamine, the VF,Pr/VF,Hct was near unity (1.05 +/- 0.11), which indicated that the blood proteins and the red blood cells had concentrated equally. Thus the transudate was essentially protein free. On exposure to histamine (3.8 +/- 0.3 microgram base/ml blood), VF,Pr/VF,Hct decreased to 0.37 +/- 0.06 (P less than 0.001), which indicated that coronary vascular permeability had increased. This value remained constant throughout the 60 min of histamine exposure. Aortic perfusion pressure decreased significantly (P less than 0.05) from 111 +/- 11 to 84 +/- 5 mmHg during the 1st min of histamine exposure and rose slowly thereafter. In four of the seven hearts, concomitant increases in left ventricular isovolumic pressure development (13-31 mmHg) and heart rate (4-29 beats/min) were observed. In the remaining hearts, neither variable was affected by histamine. We conclude that histamine causes an increase in the permeability of the canine coronary microvasculature but fails to increase heart rate or left ventricular performance consistently.