Tandem Imine Formation and Alkyne Metathesis Enabled by Catalyst Choice
Tandem Imine Formation and Alkyne Metathesis Enabled by Catalyst Choice
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DOI：
10.1021/acs.joc.2c00538
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发表时间：
2022-06-09
影响因子：
3.6
通讯作者：
Moore, Jeffrey S.
中科院分区：
文献类型：
--
作者：
Greenlee, Andrew J.;Chen, Heyu;Moore, Jeffrey S.
通过串联亚胺缩合和炔复分解反应，一锅法合成了三阶分子梯8。催化剂VI被证明成功地引起含亚胺的基质7的复分解，而催化剂III没有。催化剂VI的敏感性失活的水解和配体交换证明。在存在和不存在刘易斯酸催化剂的情况下，证明了梯8在一个罐中的组装和拆卸。
Three-rung molecular ladder 8 was prepared in one pot via tandem imine condensation and alkyne metathesis. Catalyst VI is demonstrated to successfully engender the metathesis of imine-bearing substrate 7, while catalyst III does not. The susceptibility of catalyst VI to deactivation by hydrolysis and ligand exchange is demonstrated. Assembly and disassembly of ladder 8 in one pot were demonstrated in the presence and absence of a Lewis acid catalyst.