THE ASSOCIATION OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS WITH UPPER GASTROINTESTINAL-TRACT BLEEDING
THE ASSOCIATION OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS WITH UPPER GASTROINTESTINAL-TRACT BLEEDING
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DOI：
10.1001/archinte.147.1.85
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发表时间：
1987-01-01
影响因子：
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通讯作者：
MORSE, ML
中科院分区：
文献类型：
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作者：
CARSON, JL;STROM, BL;MORSE, ML
为了评价非甾体类抗炎药（NSAID）导致上消化道（UGI）出血的风险，使用计算机化数据库进行了一项回顾性（历史）队列研究，该数据库包括密歇根州和明尼苏达州所有Medicald患者的1980年账单数据。将47，136名暴露患者与44，634名未暴露患者进行比较，暴露于NSAID后30天发生UGI出血的未校正相对风险为1.5（95%置信区间为1.2至2.0）。单变量分析表明UGl出血与年龄、性别、状态、酒精相关诊断、先前存在的腹部状况和抗凝剂的使用之间的关联。在使用逻辑回归调整这些潜在的混杂变量后，NSAID和UG 1出血之间的这种关联没有改变。线性剂量-反应关系和二次持续时间-反应关系被证明。非留体抗炎药与UGl出血相关，尽管增加的风险的大小令人放心地小。
To evaluate the risk of developing upper gastrointestinal (UGI) bleeding from nonsteroidal anti-inflammatory drugs (NSAIDs), a retrospective (historical) cohort study was performed, using a computerized data base including 1980 billing data from all Medicald patients in the states of Michigan and Minnesota. Comparing 47,136 exposed patients to 44,634 unexposed patients, the unadjusted relative risk for developing UGI bleeding 30 days after exposure to a NSAID was 1.5 (95% confidence interval 1.2 to 2.0). Univariate analyses demonstrated associations between UGl bleeding and age, sex, state, alcohol-related diagnoses, preexisting abdominal conditions, and use of anticoagulants. This association between NSAIDs and UGl bleeding was unchanged after adjusting for these potential confounding variables using logistic regression. A linear dose-response relationship and a quadratic duration-response relationship were demonstrated. Non-steroidal anti-inflammatory drugs are associated with UGl bleeding, although the magnitude of the increased risk is reassuringly small.