Inverse correlation between endothelin-1-induced peripheral microvascular vasoconstriction and blood pressure in glaucoma patients
Inverse correlation between endothelin-1-induced peripheral microvascular vasoconstriction and blood pressure in glaucoma patients
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DOI：
10.1007/bf00946939
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发表时间：
1997-10-01
影响因子：
2.7
通讯作者：
Haefeli, WE
中科院分区：
文献类型：
--
作者：
Gass, A;Flammer, J;Haefeli, WE
工作背景：有效的血管收缩肽内皮素-1已被证明参与外周血管张力的控制和眼灌注的调节。在青光眼患者中，血管痉挛和动脉低血压已被确定为青光眼损害进展的危险因素，并且在这些患者中的一些患者中内皮素-1释放的调节被干扰。本研究的目的是评估青光眼患者和匹配对照组的静息血压与皮肤血管对内皮素-1和苯肾上腺素的反应性之间的关系。研究方法：在9例原发性开角型青光眼（POAG），7例正常眼压性青光眼（NTG），和16名年龄和性别匹配的对照，内皮素-1和苯肾上腺素反应进行了评估，在人前臂微循环中使用激光多普勒血流仪动脉内给药。动脉内测量血压。结果如下：与α 1肾上腺素能效应相反，青光眼患者内皮素-1反应与收缩压（r（2）= 0.27，P = 0.05）和舒张压（r（2）= 0.54，P = 0.001）呈负相关，而对照组无此相关性，低血压患者对内皮素-1的血管收缩作用更敏感，青光眼患者和对照组对内皮素-1和苯肾上腺素的皮肤反应性相似。结论：这些结果表明，青光眼患者似乎有外周微血管异常，表现为对内皮素-1的反应性改变。因此，这项研究支持了内皮素-1相关的微血管功能障碍可能参与脑血管损伤的发病机制的假设。
Background: The potent vasoconstrictor peptide endothelin-1 has been shown to participate in the control of peripheral vascular tone and in the regulation of ocular perfusion, In glaucoma patients vasospasms and arterial hypotension have been identified as risk factors for the progression of glaucomatous damage, and the regulation of endothelin-1 release is disturbed in some of these patients. The aim of this study was to assess the relationship between resting blood pressure and cutaneous vascular responsiveness to endothelin-1 and phenylephrine in patients with glaucoma and in matched controls. Methods: In 9 patients with primary open-angle glaucoma (POAG), 7 patients with normal tension glaucoma (NTG), and 16 age-and sex-matched controls, endothelin-1 and phenylephrine responses were assessed in the human forearm microcirculation using laser Doppler flowmetry during intra-arterial drug administration. Blood pressure was measured intraarterially. Results: In contrast to alpha(1)-adrenergic effects, endothelin-1 responses were inversely correlated to both systolic (r(2) = 0.27, P = 0.05) and diastolic (r(2) = 0.54, P = 0.001) blood pressure in glaucoma patients, whereas there was no such correlation in controls, Patients with lower blood pressure values were more sensitive to the vasoconstrictor effects of endothelin-1, Cutaneous responsiveness to endothelin-1 and phenylephrine was similar in glaucoma patients and in controls. Conclusion: These-results reveal that glaucoma patients appear to have peripheral microvascular abnormalities which are exhibited as altered responsiveness to endothelin-1. Thus, this study supports the hypothesis that endothelin-1-related microvascular dysfunction may be involved in the pathogenesis of glaucomatous damage.