Chiral liquid membrane for enantioselective separation of racemic ibuprofen by L-tartaric acid derivatives
Chiral liquid membrane for enantioselective separation of racemic ibuprofen by L-tartaric acid derivatives
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DOI：
10.1039/c5ra04764a
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发表时间：
2015-05
期刊：
影响因子：
3.9
通讯作者：
Fan Zhang;Lichao He;Wei Sun;Y. Cheng;Junteng Liu;Zhongqi Ren
中科院分区：
文献类型：
--
作者：
Fan Zhang;Lichao He;Wei Sun;Y. Cheng;Junteng Liu;Zhongqi Ren
药物的手性在大多数化学和生化过程中起着重要的作用。本文研究了以正辛烷溶解的L酒石酸酯为液膜相，以聚偏氟乙烯中空纤维为膜载体的手性液膜分离布洛芬外消旋的方法。L-酒石酸二戊酯的分离系数为1.18。较佳的L-酒石酸二戊酯浓度为0.20molL−1。随着两侧流速的增加，汽提相中传质通量没有发生变化。在进料阶段也有相同的趋势。反萃相中R-布洛芬和S-布洛芬的浓度均随pH值的升高而增加。反萃相的最佳pH值为2.5，分离系数约为1.2。经过六级实验，最佳分离因子达到1.38。
The chirality of drugs plays a significant role in most chemical and biochemical process. In this paper, a chiral liquid membrane using L-tartaric ester dissolved in n-octane as liquid membrane phase and polyvinylidene fluoride hollow fibers as membrane support was investigated to separate racemic ibuprofen. For L-dipentyl tartaric ester, the separation factor was 1.18. The favorable L-dipentyl tartaric ester concentration was 0.20 mol L−1. With an increase of flow rates on two sides, a flux change of mass transfer in stripping phase was not observed. The same trend is obtained in feed phase. The concentration of both R-ibuprofen and S-ibuprofen in stripping phase increased with an increase of pH value. The best pH in stripping phase was 2.5 and the separation factor was about 1.2. The best separation factor was up to 1.38 after a six-level experiment.