Induced pluripotent stem cells: how to deal with the developmental potential
Induced pluripotent stem cells: how to deal with the developmental potential
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DOI：
10.1016/s1472-6483(10)60062-4
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发表时间：
2009-07-01
影响因子：
4
通讯作者：
Denker, Hans-Werner
中科院分区：
文献类型：
--
作者：
Denker, Hans-Werner
胚胎干细胞和诱导多能干细胞研究的最新进展表明，细胞的潜能应该成为干细胞研究伦理和政策的新焦点。有报道称，利用四倍体互补成功地从诱导多能干细胞中重建可存活的胚胎，并为从这些细胞中直接克隆个体提供了一条途径。在诱导多能干细胞技术出现并在世界范围内传播之后，这与最近对胚胎干细胞培养中原肠胚形成和模式形成过程的观察结果一起具有相当大的伦理相关性。哺乳动物胚胎学分子基础的现有知识，现在使设想技术上处理干细胞潜力的伦理困境的方法成为可能。
Recent developments in research on embryonic stem cells and induced pluripotent stem cells suggest that potentiality of cells should be a new focus in stem cell research ethics and policy. Successful reconstitution of viable embryos from induced pluripotent stem cells using tetraploid complementation has been reported and indicates a way for direct cloning of individuals from these cells. This together with recent observations on gastrulation and pattern formation processes in cultures of embryonic stem cells has considerable ethical relevance after the advent and worldwide spread of induced pluripotent stem cell technology. Available knowledge of the molecular basis of mammalian embryology now makes it possible to envisage ways to deal technically with the ethical dilemma of stem cell potentiality.