The noncalciotropic actions of vitamin D: recent clinical developments.
The noncalciotropic actions of vitamin D: recent clinical developments.
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DOI：
10.1097/mnh.0b013e3283040c99
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发表时间：
2008-07
影响因子：
3.2
通讯作者：
Maalouf NM
中科院分区：
文献类型：
--
作者：
Maalouf NM
This review summarizes recently described actions of 1,25-dihydroxyvitamin D beyond its function in calcium homeostasis and bone metabolism. 1,25-dihydroxyvitamin D stimulates the innate immune system, facilitating the clearance of infections such as tuberculosis. Hypovitaminosis D has been associated with several autoimmune disorders, various malignancies, and cardiovascular risk factors in a number of recent epidemiologic reports. Based on these observational reports, vitamin D and its analogues are being evaluated for the prevention and treatment of a variety of conditions, with early findings showing mixed results. The broad tissue distribution of the 25-hydroxyvitamin D 1α-hydroxylase enzyme and the vitamin D receptor establish a role for 1,25-dihydroxyvitamin D in the pathophysiology of various disease states and provide new therapeutic targets for vitamin D and its analogues.
