Energy-type estimates and global solvability in a two-dimensional chemotaxis–haptotaxis model with remodeling of non-diffusible attractant

Energy-type estimates and global solvability in a two-dimensional chemotaxis–haptotaxis model with remodeling of non-diffusible attractant
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重构非扩散引诱剂的二维趋化-趋触模型中的能量类型估计和全局可解性

DOI:
10.1016/j.jde.2014.04.014
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发表时间:
2014-08
影响因子:
2.4
通讯作者:
Michael Winkler
Michael Winkler
中科院分区:
数学2区
文献类型:
--
作者:
Youshan Tao;Michael Winkler

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本文研究了Chaplain和Lolas(2006)[10]首次提出的描述癌细胞间相互作用的趋化性-趋触性耦合模型{ut = Δ u− χ(u v)−(u w)+ μ u(1− u− w),x ∈ Ω,t> 0,0= Δ v+ u− v,x ∈ Ω,t> 0,w t=− v w+ η w(1− w− u),x∈ Ω,t> 0,在癌细胞侵入组织(细胞外基质)的过程中,基质降解酶和宿主组织。这里Ω <$R2是一个边界光滑的有界区域,χ,μ,η是正参数.与以前的数学研究相比,这里的新奇包括允许η的正值,反映了细胞外基质的自我重塑过程。在零通量边界条件下,证明了对于满足一阶相容条件的任意充分光滑初值(u 0,w 0),模型存在唯一的整体光滑解.证明中的一个关键要素是一个类似能量的不等式,给定T> 0,该不等式产生u(n,t)在L log L(Ω)中的有界性。这作为一个起点的引导参数,用于获得更高的正则性估计足够的全球可扩展性的解决方案。
This paper deals with the coupled chemotaxis–haptotaxis model {u t= Δ u− χ∇⋅(u∇ v)− ξ∇⋅(u∇ w)+ μ u (1− u− w), x∈ Ω, t> 0, 0= Δ v+ u− v, x∈ Ω, t> 0, w t=− v w+ η w (1− w− u), x∈ Ω, t> 0, which was initially proposed by Chaplain and Lolas (2006)[10] to describe the interactions between cancer cells, the matrix degrading enzyme and the host tissue in a process of cancer cell invasion of tissue (extracellular matrix). Here, Ω⊂ R 2 is a bounded domain with smooth boundary, and χ, ξ, μ and η are positive parameters. As compared to previous mathematical studies, the novelty here consists of allowing for positive values of η, reflecting processes of self-remodeling of the extracellular matrix. Under zero-flux boundary conditions, it is shown that for any sufficiently smooth initial data (u 0, w 0) satisfying first-order compatibility conditions, the model admits a unique global smooth solution. A crucial ingredient in the proof is an energy-like inequality which, given T> 0, yields boundedness of u (⋅, t) in L log L (Ω). This serves as a starting point for a bootstrap argument used to derive higher regularity estimates sufficient for global extensibility of solutions.
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