Establishing the cross-cultural applicability of a harmonized approach to cognitive diagnostics in epilepsy: Initial results of the International Classification of Cognitive Disorders in Epilepsy in a Spanish-speaking sample.
Establishing the cross-cultural applicability of a harmonized approach to cognitive diagnostics in epilepsy: Initial results of the International Classification of Cognitive Disorders in Epilepsy in a Spanish-speaking sample.
复制标题
建立癫痫认知诊断统一方法的跨文化适用性：癫痫认知障碍国际分类在西班牙语样本中的初步结果。
DOI：
10.1111/epi.17501
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发表时间：
2023
期刊：
影响因子：
5.6
通讯作者：
McDonald,CarrieR
中科院分区：
文献类型：
--
作者：
Reyes,Anny;Salinas,Lilian;Hermann,BruceP;Baxendale,Sallie;Busch,RobynM;Barr,WilliamB;McDonald,CarrieR
本研究旨在评估国际癫痫认知障碍分类(IC-CODE)在居住在美国的讲西班牙语的颞叶癫痫(TLE)患者中的跨文化应用。方法84例讲西班牙语的TLE患者完成了记忆、语言、执行功能、视觉空间功能和注意力/加工速度的神经心理学测量，作为拉美裔神经心理筛查的一部分。评估了人口统计学和临床变量对认知表现的贡献。通过检查几个损伤阈值的基本损伤率进行了敏感性分析。然后应用IC代码分类，并计算每个截断点的认知表型的基本比率。表型的分布与已发表的IC代码分类数据进行比较，该数据利用了大量多中心的说英语的TLEs患者队列。结果在不同的损害界限中，记忆是最严重的认知领域，在列表学习方面的损害从50%到78%不等。应用采用−1.5-SD标准的IC代码分类显示，47.6%的患者认知特征完整，23.8%的患者存在单一领域损害，14.3%的患者存在双相损害，14.3%的患者存在全身性损害。这一分布与IC代码验证样本中观察到的表型分布类似。意义我们在讲西班牙语的癫痫队列中与讲英语的样本中展示了类似的认知表型模式和分布。这表明与TLE相关的潜在表型的稳定性，以及IC代码在指导癫痫研究中的认知诊断方面的适用性，可以应用于文化和语言上不同的样本。
ObjectiveThis study was undertaken to evaluate the cross‐cultural application of the International Classification of Cognitive Disorders in Epilepsy (IC‐CoDE) to a cohort of Spanish‐speaking patients with temporal lobe epilepsy (TLE) living in the United States.MethodsEighty‐four Spanish‐speaking patients with TLE completed neuropsychological measures of memory, language, executive function, visuospatial functioning, and attention/processing speed as part of the Neuropsychological Screening Battery for Hispanics. The contribution of demographic and clinical variables to cognitive performance was evaluated. A sensitivity analysis was conducted by examining the base rates of impairment across several impairment thresholds. The IC‐CoDE taxonomy was then applied, and the base rate of cognitive phenotypes for each cutoff was calculated. The distribution of phenotypes was compared to the published IC‐CoDE taxonomy data, which utilized a large, multicenter cohort of English‐speaking patients with TLE.ResultsAcross the different impairment cutoffs, memory was the most impaired cognitive domain, with impairments in list learning ranging from 50% to 78%. Application of the IC‐CoDE taxonomy utilizing a −1.5‐SD cutoff revealed an intact cognitive profile in 47.6% of patients, single‐domain impairment in 23.8% of patients, bidomain impairment in 14.3% of patients, and generalized impairment in 14.3% of the sample. This distribution was comparable to the phenotype distribution observed in the IC‐CoDE validation sample.SignificanceWe demonstrate a similar pattern and distribution of cognitive phenotypes in a Spanish‐speaking epilepsy cohort compared to an English‐speaking sample. This suggests stability in the underlying phenotypes associated with TLE and applicability of the IC‐CoDE for guiding cognitive diagnostics in epilepsy research that can be applied to culturally and linguistically diverse samples.