SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels.
SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels.
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DOI：
10.1111/j.1600-065x.2008.00760.x
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发表时间：
2009-03
影响因子：
8.7
通讯作者：
Lorenz U
中科院分区：
文献类型：
--
作者：
Lorenz U
蛋白质的酪氨酸磷酸化和去磷酸化对许多T细胞功能起关键作用。蛋白酪氨酸激酶（PTK）和蛋白酪氨酸磷酸酶（PTPs）的相反作用决定了任何时候酪氨酸磷酸化的水平。人们普遍认为PTK在T细胞信号传导过程中是必不可少的;然而，PTPs的作用和重要性却鲜为人知。跨膜和细胞质酪氨酸磷酸酶都已在T细胞中鉴定，并显示出调节T细胞应答。本文综述了两个胞质PTP，Src同源2结构域（SH 2）-含有SHP-1和SHP-2，在T细胞信号转导，发育，分化和功能的作用。
Tyrosine phosphorylation and dephosphorylation of proteins play a critical role for many T-cell functions. The opposing actions of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs) determine the level of tyrosine phosphorylation at any time. It is well accepted that PTKs are essential during T-cell signaling; however, the role and importance of PTPs are much less known and appreciated. Both transmembrane and cytoplasmic tyrosine phosphatases have been identified in T cells and shown to regulate T-cell responses. This review focuses on the roles of the two cytoplasmic PTPs, the Src-homology 2 domain (SH2)-containing SHP-1 and SHP-2, in T-cell signaling, development, differentiation, and function.
Motheaten（ME/ME）和可行的Motheaten（MEV/MEV）突变小鼠的骨髓中的淋巴管缺陷。 I.分析促炎细胞，早期B谱系细胞和末端脱氧核苷酸转移酶阳性细胞的发育。
影响因子：
15.3
作者：
Greiner, D L;Goldschneider, I;Komschlies, K L;Medlock, E S;Bollum, F J;Schultz, L
通讯作者：
Schultz, L