Freeze-thaw and solvent-exchange strategy to generate physically cross-linked organogels and hydrogels of curdlan with tunable mechanical properties.
Freeze-thaw and solvent-exchange strategy to generate physically cross-linked organogels and hydrogels of curdlan with tunable mechanical properties.
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DOI：
10.1016/j.carbpol.2021.119003
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发表时间：
2022-02
影响因子：
11.2
通讯作者：
Min Wu;Xiaoxia Chen;Jiatong Xu;Hongbin Zhang
中科院分区：
文献类型：
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作者：
Min Wu;Xiaoxia Chen;Jiatong Xu;Hongbin Zhang
天然多糖的物理凝胶具有无毒性交联剂和制备过程中无化学改性的优点。本文采用冻融技术，在二甲基亚砜（DMSO）中制备了来自微生物来源的（1，3）-β-D-葡聚糖凝胶的新型物理凝胶、透明有机凝胶和不透明水凝胶，然后用水进行溶剂交换。通过流变学、扫描电子显微镜、衰减全反射红外光谱、广角X射线衍射和小角X射线散射研究了这些凝胶的力学和结构性能。还提出了甘精胰岛素机制和分子间相互作用模型。良好的溶剂DMSO在有机凝胶中既作为交联剂又作为致孔剂。可得然胶大分子的可逆构象变化和相分离使凝胶具有可逆的透明性、体积变化和可调的机械强度。新的设计策略，方便的制备和性能调整提供了一个平台，开发新的有机凝胶和无菌水凝胶的可得然胶。
Physical gels from natural polysaccharides present the advantage of no toxic cross-linking agents and no chemical modification during preparation. Herein, novel physical gels, transparent organogels and opaque hydrogels from the microorganism-derived (1,3)-β-D-glucan of curdlan were prepared in dimethyl sulfoxide (DMSO) using the freeze-thaw technique, followed by a solvent-exchange strategy with water. The mechanical and structural properties of these gels were investigated by rheology, scanning electron microscopy, attenuated total reflection infrared spectroscopy, wide-angle X-ray diffraction and small-angle X-ray scattering. Gelation mechanisms and intermolecular interaction models have also been proposed. The good solvent DMSO serves as both a crosslinker and a pore-foaming agent in organogels. The reversible macromolecular conformation changes and phase separation of curdlan endow the gels with reversible transparency, volume change and tunable mechanical strength. The new design strategy of facile preparation and performance tuning provides a platform for developing new organogels and sterile hydrogels of curdlan.