Detecting dose response with contrasts.
Detecting dose response with contrasts.
复制标题
通过对比检测剂量反应。
DOI：
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发表时间：
2000
影响因子：
2
通讯作者：
Stephen J. Ruberg
中科院分区：
文献类型：
--
作者：
William H. Stewart;Stephen J. Ruberg
剂量反应研究的分析应将是否存在剂量反应关系的问题与功能形式和寻找最佳剂量的问题分开。在所研究剂量的估计效应之间精心选择的对比，可以成为检测剂量反应关系是否存在的有力检验。当系数的模式与真实的剂量反应关系具有相同的形状时，基于对比的试验达到了最大的功效。然而，当对比形状与真实剂量响应形状不相似时，它会失去功率。因此，基于单一对比的主要测试通常是有风险的。两个（或更多）适当选择的对比可以确保足够的力量来证明多重调整的成本。一个例子显示了双重对比法在检测剂量反应方面的成功，这使几种标准方法受挫。
Analyses of dose response studies should separate the question of the existence of a dose response relationship from questions of functional form and finding the optimal dose. A well-chosen contrast among the estimated effects of the studied doses can make a powerful test for detecting the existence of a dose response relationship. A contrast-based test attains its greatest power when the pattern of the coefficients has the same shape as the true dose response relationship. However, it loses power when the contrast shape and the true dose response shape are not similar. Thus, a primary test based on a single contrast is often risky. Two (or more) appropriately chosen contrasts can assure sufficient power to justify the cost of a multiplicity adjustment. An example shows the success of a two-contrast procedure in detecting dose response, which had frustrated several standard procedures.
影响因子：
1.9
作者：
EDWARDS, D;BERRY, JJ
通讯作者：
BERRY, JJ